Press Release on Antibiotic Research: August-2018

Scientists Just Announced Our Best Shot at Ending Antibiotic Resistance to Date

Scientists have developed a molecule that reverses antibiotic resistance in multiple strains of bacterium right away, creating it one amongst the foremost promising advances we’ve had thus far within the fight against superbugs.

The announcement could not return at a much better time – within the past week, researchers have reportedĀ  that a North American nation lady was killed by a Bemisia tabaci proof against each offered antibiotic, which antibiotic resistance is currently spreading quicker and additional stealthily than they’d expected. within the war against superbugs, we’re presently losing. [1]

Use of broad-spectrum antibiotics impacts outcome in patients treated with immune checkpoint inhibitors

We allotted a retrospective cohort study on patients with advanced cancer treated with immune stop inhibitors (ICIs) to see whether or not antibiotics have an effect on treatment outcome. Sixty consecutive patients were known, and seventeen received general antibiotics at intervals a pair of weeks before and/or once 1st dose of ICI. Antibiotic-treated patients were considerably younger (p = zero.0008) and fewer probably to receive nivolumab (p = zero.08) or had neutrophil:lymphocyte magnitude relation < five (p = zero.08). that they had a lower response rate (RR) (29.4% vs 62.8%) (p = 0.024) and a lot of inferior progression-free survival (PFS) (p = zero.048). Narrow-spectrum antibiotics didn’t have an effect on the RR. However, broad-spectrum antibiotics were related to a lower RR (25% vs 61%) (p = zero.02) and a trend towards longer time to response (median: fourteen weeks vs twelve weeks) (p = zero.1). They conjointly had shorter PFS (p = zero.012). statistical method known antibiotics because the solely issue poignant RR (p = zero.0038) and PFS (p = zero.01). we have a tendency to next examined the twenty one patients whose PFS lasted for twelve weeks or a lot of. [2]

Improving Time to Antibiotics for Pediatric Oncology Patients With Fever and Suspected Neutropenia by Applying Lean Principles

Background : Fever within the setting of leucopenia could be a probably dangerous complication of cancer treatment. A time of below hr from presentation to antibiotic administration is thus suggested.

Objective : To use Lean Six letter methodology, a high quality improvement initiative, to enhance time to antibiotics (TTA) for youngsters with chemotherapy-induced febrileĀ  leucopenia presenting to the emergency department. [3]

A Retrospective Surveillance of the Antibiotics Prophylactic Use of Surgical Procedures in Private Hospitals in Indonesia

Background: per international tips, prophylactic antibiotics in elective surgery ought to lean as one dose thirty to hour before the operation is conducted. operative administration of antibiotics ought to be out of print twenty four hours when surgery to attenuate microorganism resistance and to stay management over hospitalization prices. there’s a scarcity of information on the particular antibiotic use around surgical procedures in Republic of Indonesia. Objective: This retrospective police investigation study aimed to get outlined daily doses (DDD) and DDDs per one hundred bed days (DDD-100BD) for prophylactically used antibiotics in 2 non-public hospitals in Surabaya, East Java. These hospitals square measure thought-about to be representative for this scenario in Republic of Indonesia. [4]

The Effectiveness of Antibiotics in the Prevention of Salmonella Typhimurium in Growing Chickens

Aims: The aim of this study was to analyze the effectiveness of medication within the hindrance of enteric bacteria in growing chickens.

Material associate degreed Methods: All specimens were placed in an shack with ice packs and transported to the laboratory for analysis. bacteriologic media obtained from Difco Laboratories port MI U.S.A were used for the isolation and identification of enteric bacteria spp. enteric bacteria serologic typewriting was performed to see the enteric bacteria serovar by customary procedures. Chickens got one dose of a wild-type multiresistant strain of Salmonella typhimurium (resistant to several antibiotics together with cloramphenicol and bactrim) by oral route (3×109 cfu/bird) as a challenge.

Results: The effectiveness of some medications within the reduction of enteric bacteria infections in growing chicken unconcealed that none of the teams together with the management cluster showed any clinical signs of food poisoning. However, post-mortem specimens together with caeca showed the presence of enteric bacteria in one.6 % (1/60) every of chickens treated with Menorox and Neochlore, compared to twenty third (14/60) among the management cluster. [5]

Reference

[1] Scientists Just Announced Our Best Shot at Ending Antibiotic Resistance to Date

FIONA MACDONALD, 21 JAN 2017 (web link)

[2] Use of broad-spectrum antibiotics impacts outcome in patients treated with immune checkpoint inhibitors

Ahmed J, Kumar A, Parikh K, Anwar A, Knoll BM, Puccio C, Chun H, Fanucchi M, Lim SH. Use of broad-spectrum antibiotics impacts outcome in patients treated with immune checkpoint inhibitors. OncoImmunology. 2018 Aug 19:1-6. (web link)

[3] Improving Time to Antibiotics for Pediatric Oncology Patients With Fever and Suspected Neutropenia by Applying Lean Principles

Geerlinks AV, Digout C, Bernstein M, Chan A, MacPhee S, Pambrun C, Gallant G, Wyatt L, Fernandez CV, Price VE. Improving Time to Antibiotics for Pediatric Oncology Patients With Fever and Suspected Neutropenia by Applying Lean Principles. Pediatric Emergency Care. 2018 Aug 20. (web link)

[4] A Retrospective Surveillance of the Antibiotics Prophylactic Use of Surgical Procedures in Private Hospitals in Indonesia

Herawati F, Yulia R, Hak E, Hartono AH, Michiels T, Woerdenbag HJ, Avanti C. A Retrospective Surveillance of the Antibiotics Prophylactic Use of Surgical Procedures in Private Hospitals in Indonesia. Hospital Pharmacy. 2018 Aug 21:0018578718792804. (web link)

[5] The Effectiveness of Antibiotics in the Prevention of Salmonella Typhimurium in Growing Chickens

ALVEN SSuzette Curtello1, Angel Alberto Justiz Vaillant2*, Helen Asemota1, Patrick E. Akpaka2 and Monica P. Smikle3

1Biochemistry Section, Department of Basic Medical Sciences, The University of the West Indies, Mona campus, Jamaica.
2Pathology and Microbiology Unit, Department of Para-Clinical Sciences, The University of the West Indies, Saint Augustine, Trinidad and Tobago.
3Department of Microbiology, University Hospital of West Indies, Jamaica. (web link)

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