News Release on Newcastle Disease Virus Research: September-2018

Newcastle Virus Shows Promise As Prostate Cancer Treatment

A recombinant animal disease virus kills all types of prostatic adenocarcinoma cells, as well as internal secretion resistant cells, however leaves traditional cells unharmed, in line with a paper printed on-line previous print within the Journal of medical specialty.

A treatment for prostatic adenocarcinoma supported this virus would avoid the adverse aspect effects generally related to secretion treatment for prostatic adenocarcinoma, still as those related to cancer chemotherapies usually, says corresponding author Subbiah Elankumaran of Virginia Tech, Blacksburg. The changed virus is currently able to be tested in diagnosis animal models, and probably in clinical trial human clinical trials. [1]

Newcastle disease virus V protein inhibits cell apoptosis and promotes viral replication by targeting CacyBP/SIP

Newcastle disease virus (NDV) has been classified by the globe Organization for Animal Health (OIE) as a notable disease-causing virus, and this virus has the flexibility to infect a good variety of birds. V supermolecule could be a non-structural supermolecule of NDV. V supermolecule has been reportable to inhibit cell caspase-mediated cell death (Park, et al., 2003a) and promote microorganism replication(Huang, et al., 2003), however, the mechanisms of action of V supermolecule haven’t been elucidated. within the gift study, a yeast two-hybrid screen was performed, and V supermolecule was found to move with the CacyBP/SIP supermolecule. The results of co-immunoprecipitation and immuno-colocalization assays confirmed the interaction between V supermolecule and CacyBP/SIP. [2]

Low dose velogenic viscerotropic Newcastle disease virus infection caused 30% mortalities in Anak broilers but none in Lohmann Brown layer chickens

The aim of this project was to search out the comparative susceptibilities of broilers and layer chickens to an occasional dose of velogenic viscerotropic animal disease virus (vvNDV) infection victimization mortalities because of the main indicator. 5 weeks previous Anak broilers and Lohmann Brown layer chicks were inoculated with vvNDV. The birds were monitored daily for clinical signs and sickness evolution was evaluated. Clinical signs consisting of depression and looseness of the bowels appeared at three days post-inoculation (DPI) in broilers and at a pair of DPI in layer chickens leading to total mortalities of half-hour and 1/3 in broilers and layer chickens, severally. [3]

Comparative analysis of early immune responses induced by two strains of Newcastle disease virus in chickens

Newcastle illness, caused by a virulent strain of Newcastle disease virus (NDV), is associate degree acute, extremely communicable disease that’s prevailing worldwide and is answerable for serious economic losses to the poultry trade. within the current study, we tend to compare the first immune responses in chickens infected with 2 strains of velogenic NDV, a duck origin, named GD strain (Md/CH/LGD/1/2005, genotype VIId), associate degreed a chicken origin, F48E9 strain (genotype IX). The microorganism RNA level of GD strain was considerably on top of those of F48E9 in most tissues of chicken. [4]

Strains of Newcastle disease Virus, Circulating among Sick Poultry Flocks in Nsukka-Nigeria

Aim: to check prevalence of the various strains of Newcastle disease virus (NDV) current among sick poultry flocks, NDV detected from illness outbreaks in Nsukka-Nigeria were characterized into the 3 main NDV strains.

Materials and Methods: NDV was detected from sixty-three cases of poultry illness that manifested clinical signs and lesions connotative Newcastle disease (ND), by the hemagglutination take a look at. The detected NDV samples were characterized by a mixture of their ability to agglutinate class RBCs and their erythrocyte extraction time (EET). [5]

Reference

[1] Newcastle Virus Shows Promise As Prostate Cancer Treatment

February 26, 2013 (web link)

[2] Newcastle disease virus V protein inhibits cell apoptosis and promotes viral replication by targeting CacyBP/SIP

Chu Z, Wang C, Tang Q, Shi X, Gao X, Ma J, Lu K, Han Q, Jia Y, Wang X, Adam FE. Newcastle disease virus V protein inhibits cell apoptosis and promotes viral replication by targeting CacyBP/SIP. Frontiers in Cellular and Infection Microbiology. 2018;8:304. (web link)

[3] Low dose velogenic viscerotropic Newcastle disease virus infection caused 30% mortalities in Anak broilers but none in Lohmann Brown layer chickens

Omeke JN, Ezema WS, Eze DC, Okoye JO. Low dose velogenic viscerotropic Newcastle disease virus infection caused 30% mortalities in Anak broilers but none in Lohmann Brown layer chickens. Journal of Applied Animal Research. 2018 Jan 1;46(1):1352-7. (web link)

[4] Comparative analysis of early immune responses induced by two strains of Newcastle disease virus in chickens

Zhang T, Ren M, Liu C, Xu L, Wang F, Han Z, Shao Y, Ma D. Comparative analysis of early immune responses induced by two strains of Newcastle disease virus in chickens. MicrobiologyOpen. 2018 Aug 1:e00701. (web link)

[5] Strains of Newcastle disease Virus, Circulating among Sick Poultry Flocks in Nsukka-Nigeria

Maduike C. O. Ezeibe1*, John A. O. Okoye2, Ihuoma E. Ezeala2, Ijeoma J. Mbuko1 and Augustine A. Ngene2

1Department of Veterinary Medicine,Michael Okpara University of Agriculture, Umudike, Nigeria.

2Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria. (web link)