Latest Research on Aedes Aegypti: Dec – 2019

Genome Sequence of Aedes aegypti, a Major Arbovirus Vector

We gift a draft collection of the genome of Aedes aegypti, the number one vector for yellow fever and dengue fever, which at ∼1376 million base pairs is about 5 instances the size of the genome of the malaria vector Anopheles gambiae. Nearly 50% of the Ae. Aegypti genome includes transposable elements. These make a contribution to a element of ∼4 to six boom in common gene duration and in sizes of intergenic areas relative to An. Gambiae and Drosophila melanogaster. Nonetheless, chromosomal synteny is typically maintained amongst all three insects, although conservation of orthologous gene order is higher (via a issue of ∼2) among the mosquito species than among both of them and the fruit fly. An boom in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. Gambiae suggests that participants of these protein families underpin a number of the organic differences among the 2 mosquito species. [1]

Flavivirus Susceptibility in Aedes aegypti

Aedes aegypti is the primary vector of yellow fever (YF) and dengue fever (DF) flaviviruses worldwide. In this review we recognition on past and gift studies on genetic components and environmental factors in Aedes aegypti that appear to manipulate flavivirus transmission. We assessment genetic relationships amongst Ae. Aegypti populations throughout the arena and talk how variation in vector competence is correlated with average genetic variations among populations. We describe contemporary research into how genetic and environmental factors collectively have an effect on distribution of vector competence in herbal populations. Based in this information, we suggest a populace genetic model for vector competence and talk our current progress in trying out this version. We quit with a dialogue of techniques being taken to pick out the genes that could control flavivirus susceptibility in Ae. Aegypti. [2]


Yolk proteins are notion to go into positive eggs with the aid of a system corresponding to micropinocytosis however the detailed mechanism has no longer been formerly depicted. In this have a look at the formation of protein yolk turned into investigated inside the mosquito Aedes aegypti L. Ovaries have been fixed in phosphate-buffered osmium tetroxide, for electron microscopy, before and at intervals after a meal of blood. The deposition of protein yolk in the oocyte become correlated with a 15-fold increase in 140 mµ pit-like depressions at the oocyte surface. These pits form by way of invagination of the oocyte cell membrane. They have a 20 mµ bristle coat on their convex cytoplasmic facet. They additionally show a layer of protein on their concave extracellular aspect which we endorse accumulates through selective adsorption from the extraoocyte space. [3]

Dynamics and diversity of bacteria associated with the disease vectors Aedes aegypti and Aedes albopictus

Aedes aegypti and Aedes albopictus broaden in the equal aquatic web sites wherein they come upon microorganisms that have an impact on their life records and capacity to transmit human arboviruses. Some bacteria along with Wolbachia are currently being taken into consideration for the control of Dengue, Chikungunya and Zika. Yet little is known about the dynamics and variety of Aedes-associated micro organism, such as larval habitat capabilities that form their pace-spatial distribution. We implemented large-scale 16S rRNA amplicon sequencing to 960 adults and larvae of both Ae. Aegypti and Ae. Albopictus mosquitoes from 59 sampling sites widely disbursed across nine provinces of Panama. [4]

Synthesis of Novel 1,2,4-triazole-DTC Based Metallo-phosphorous Nanoformulations as Larvicide against Aedes aegypti

Aims: The present take a look at concerned the synthesis of heteroleptic steel complexes and their nanoformulations as capability larvicidal agent.

Study Design: Metal complexes nanoformulations.

Place and Duration of Study: Department of Chemistry, Punjab agricultural University, Ludhiana, Punjab, India between January 2016 and February 2017.

Methodology: Heteroleptic steel complexes of  Cu(II), Co(II) and Fe(III), using 1,2,4-triazole-dithiocarbamate, isothiocyanate and triphenyl phosphine ligands were prepared and converted to water dispersible nano-formulations using PVP (Polyvinyl pyrollidine) as capping in addition to stabilizing agent and sodium dodecyl sulfate (SDS) as surfactant. The structures of metallic complexes and their nanoformulations were characterized on the basis of elemental evaluation, spectral techniques, and TEM analysis. The anti-larval evaluation of the nano-formulations against Aedes aegypti turned into made on the basis with the aid of the standard hints of World Health Organization (2005). [5]


[1] Nene, V., Wortman, J.R., Lawson, D., Haas, B., Kodira, C., Tu, Z.J., Loftus, B., Xi, Z., Megy, K., Grabherr, M. and Ren, Q., 2007. Genome sequence of Aedes aegypti, a major arbovirus vector. Science, 316(5832), (Web Link)

[2] Black IV, W.C., Bennett, K.E., Gorrochótegui-Escalante, N., Barillas-Mury, C.V., Fernández-Salas, I., de Lourdes Muñoz, M., Farfán-Alé, J.A., Olson, K.E. and Beaty, B.J., 2002. Flavivirus susceptibility in Aedes aegypti. Archives of medical research, 33(4), (Web Link)

[3] Roth, T.F. and Porter, K.R., 1964. Yolk protein uptake in the oocyte of the mosquito Aedes aegypti. L. The Journal of cell biology, 20(2), (Web Link)

[4] Dynamics and diversity of bacteria associated with the disease vectors Aedes aegypti and Aedes albopictus
Kelly L. Bennett, Carmelo Gómez-Martínez, Yamileth Chin, Kristin Saltonstall, W. Owen McMillan, Jose R. Rovira & Jose R. Loaiza
Scientific Reports volume 9, Article number: 12160 (2019) (Web Link)

[5] Gumber, K., Sidhu, A. and K. Kocher, D. (2017) “Synthesis of Novel 1,2,4-triazole-DTC Based Metallo-phosphorous Nanoformulations as Larvicide against Aedes aegypti”, International Research Journal of Pure and Applied Chemistry, 14(1), (Web Link)

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