Latest News on Ameloblastoma Research: Jan – 2020

Ameloblastoma: Biological profile of 3677 cases

Available literature on ameloblastoma of the jaw was reviewed, including publications from 1960 to 1993, and compared to the newest larger review, published by Small and Waldron in 1955.

The average age of patients with ameloblastoma is 36 years. In developing countries ameloblastomas occur in younger patients. Men and ladies are equally affected. Women are 4 years younger than men when ameloblastomas first occur, and therefore the tumours appear to be larger in females. Dominant clinical symptoms like painless swelling and slow growth are non-characteristic. The ratio of ameloblastoma of the mandible to maxilla is 5 to 1. Ameloblastomas of the mandible occur 12 years before those of the maxilla. Ameloblastomas occur most often within the molar region of the mandible. [1]


The purpose of this text is to review the pertinent literature and discuss the optimal treatment and outcomes for patients with ameloblastoma. Ameloblastoma is an uncommon benign, locally aggressive odontogenic neoplasm that sometimes occurs within the vicinity of the mandibular molars or ramus. Uncontrolled, ameloblastoma may cause significant morbidity and infrequently death. The median age is approximately 35 years and males and females are equally affected. the bulk of ameloblastomas are multicystic, which are harder to eradicate than the unicystic and peripheral varieties. Although surgery is that the mainstay of treatment, the extent of resection is controversial. [2]

Unicystig ameloblastoma. A prognostically distinct entity

The occurrence of unicystic ameloblastoma has been studied in 20 patients presenting with unilocular cystic lesions whose clinical, radiographic and gross features were those of non‐neoplastic cysts. within the majority of those , the lesion mimicked dentigerous cyst. the speed of recurrence for this group of lesions as determined by future follow‐up observation available for the bulk of patients was distinctly less than that related to multicystic and solid ameloblastoma. This, including preservation of the unicystic character of the lesion throughout its course, is indicative of a way less aggressive sort of neoplasm. The adequacy of straightforward enucleation as a modality of treatment within the majority of patients with this sort of lesion is usually recommended. it had been impossible to answer the question whether or not the ameloblastoma began in antecedent non‐neoplastic cyst. [3]

Shark tooth regeneration reveals common stem cell characters in both human rested lamina and ameloblastoma

The human dentition may be a typical diphyodont mammalian system with tooth replacement of most positions. However, after dental replacement and sequential molar development, the dental lamina undergoes apoptosis and fragments, leaving scattered epithelial units (dental lamina rests; DLRs). DLRs in adult humans are considered inactive epithelia, thought to possess limited capacity for further regeneration. However, we show that these tissues contain alittle proportion of proliferating cells (assessed by both Ki67 and PCNA) but also express variety of common dental somatic cell markers (Sox2, Bmi1, β-catenin and PH3) almost like that observed in many vertebrates that actively, and continuously regenerate their dentition. [4]

Desmoplastic Ameloblastoma in Maxilla: A Report of Rare Case with Review of Literature and Classic Histopathology

Ameloblastoma may be a very rare odontogenic tumor of the mouth , with different histological variants. one among the kinds of ameloblastoma is desmoplastic ameloblastoma (DA) which has 4-5% of incidence. Here we review and reported the desmoplastic ameloblastoma is that the least of occurrence of all the variants of ameloblastoma. the individuality of this lesion are often further enlightened with reference to its site of occurrence, the radiographic feature and therefore the histological appearance different from the classical sort of ameloblastoma. This case report focuses on a DA that occurred within the maxilla of 25-year-old women and explains about clinical, CT scan, histopathological finding, and treatment plan. The patient is undergoing routine follow-up and is presently freed from disease. [5]


[1] Reichart, P.A., Philipsen, H.P. and Sonner, S., 1995. Ameloblastoma: biological profile of 3677 cases. European Journal of Cancer Part B: Oral Oncology, 31(2), (Web Link)

[2] Mendenhall, W.M., Werning, J.W., Fernandes, R., Malyapa, R.S. and Mendenhall, N.P., 2007. Ameloblastoma. American journal of clinical oncology, 30(6), (Web Link)

[3] Robinson, L. and Martinez, M.G., 1977. Unicystig ameloblastoma. A prognostically distinct entity. Cancer, 40(5), (Web Link)

[4] Shark tooth regeneration reveals common stem cell characters in both human rested lamina and ameloblastoma
Gareth J. Fraser, Samar S. Hamed, Kyle J. Martin & Keith D. Hunter
Scientific Reports volume 9, (Web Link)

[5] Doddawad, V. G., Shivananda, S., Subbaiah, P. and Rao, D. (2017) “Desmoplastic Ameloblastoma in Maxilla: A Report of Rare Case with Review of Literature and Classic Histopathology”, Annual Research & Review in Biology, 21(4), (Web Link)

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