Latest Research News on Arrhythmia: Jan – 2020

Sinus Arrhythmia in Acute Myocardial Infarction

Sinus arrhythmia, defined by means of a calculation of variance of die R‐R interval on admission to hospital, was present in. 73 of 176 patients admitted to a coronary care unit with acute myocardial infarct . These patients had a lower hospital mortality. They attended have a better incidence of inferior infarction, and a lower incidence of anterior infarction, and to possess smaller infarcts as measured by the Norris index. the most difference between patients with sinus arrhythmia and without sinus arrhythmia associated with heart rates on admission to hospital, the patients with the previous having slower heart rates at that point. [1]

hERG potassium channels and cardiac arrhythmia

hERG potassium channels are essential for normal electrical activity within the heart. Inherited mutations within the HERG gene cause long QT syndrome, a disorder that predisposes individuals to life-threatening arrhythmias. Arrhythmia also can be induced by a blockage of hERG channels by a surprisingly diverse group of medicine . This side effect may be a common reason for drug failure in preclinical safety trials. Insights gained from the crystal structures of other potassium channels have helped our understanding of the block of hERG channels and therefore the mechanisms of gating. [2]

The impact of the MIT-BIH Arrhythmia Database

The MIT-BIH Arrhythmia Database was the primary generally available set of ordinary test material for evaluation of arrhythmia detectors, and it’s been used for that purpose also as for basic research into cardiac dynamics at about 500 sites worldwide since 1980. it’s lived a far longer life than any of its creators ever expected. along side the American Heart Association Database, it played a stimulating role in stimulating manufacturers of arrhythmia analyzers to compete on the idea of objectively measurable performance, and far of the present appreciation of the worth of common databases, both for basic research and for medical device development and evaluation, are often attributed to the present experience. during this article, we briefly review the history of the database, describe its contents, discuss what we’ve learned about database design and construction, and take a glance at a number of the later projects that are stimulated by both the successes and therefore the limitations of the MIT-BIH Arrhythmia Database. [3]

Effects of white-coat, masked and sustained hypertension on coronary artery stenosis and cardiac arrhythmia

This study aimed to research whether hypertension phenotypes like high blood pressure (WCHT), diagnosed with the addition of nighttime vital sign (BP) criteria, are associated with arteria coronaria stenosis (CAS) and arrhythmia . during this cross-sectional observational study, 844 participants who didn’t use antihypertensive, lipid-lowering, and antiplatelet drugs were selected. the themes were divided into normotensive (NT), WCHT, masked hypertension (MHT), and sustained hypertension (SHT) groups supported the results of clinic BP measurement and ambulatory BP monitoring. Coronary angiography and ambulatory electrocardiography were performed to work out the participants’ CAS and arrhythmia status. [4]

QTc Prolongation and Arrhythmia Development in the Treatment of ICU Delirium: An Investigation of Medication-Related Risk Factors

Aims: Antipsychotics are commonly used for ICU delirium, although there’s limited data describing the danger of QTc prolongation with these therapies. This study aimed to guage the prevalence of and risk factors for QTc prolongation related to antipsychotic agents for ICU delirium.

Study Design: A retrospective cohort study of patients with ICU delirium who received an major tranquilizer .

Place and Duration of Study: The Ohio State University Wexner center Surgical and Medical ICUs, between January 1st, 2012 and January 1st, 2015.

Methodology: QTc prolongation was defined as QTc >500 ms or >20% increase from baseline. the first outcome was the prevalence of QTc prolongation. Secondary outcomes included risk factors for QTc prolongation, prevalence of Torsades de Pointes (TdP) or ventricular arrhythmias, ICU length of stay, length of delirium treatment, and all-cause ICU mortality. [5]

Reference

[1] Wolf, M.M., Varigos, G.A., Hunt, D. and Sloman, J.G., 1978. Sinus arrhythmia in acute myocardial infarction. Medical Journal of Australia, 2(2), (Web Link)

[2] Sanguinetti, M.C. and Tristani-Firouzi, M., 2006. hERG potassium channels and cardiac arrhythmia. Nature, 440(7083), (Web Link)

[3] Moody, G.B. and Mark, R.G., 2001. The impact of the MIT-BIH arrhythmia database. IEEE Engineering in Medicine and Biology Magazine, 20(3), (Web Link)

[4] Effects of white-coat, masked and sustained hypertension on coronary artery stenosis and cardiac arrhythmia
Peng Cai, Weitian Zhong, Yan Wang & Xukai Wang
Hypertension Research volume 43, (Web Link)

[5] Francis, A., Eiferman, D. S., Boyd, J., Phillips, G. and Murphy, C. V. (2018) “QTc Prolongation and Arrhythmia Development in the Treatment of ICU Delirium: An Investigation of Medication-Related Risk Factors”, Journal of Pharmaceutical Research International, 23(3), (Web Link)

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