News Update on Platelets Research: Jan – 2020

Platelets and wound healing.

Platelets help prevent blood loss at sites of vascular injury. to try to to this, they adhere, aggregate and form a procoagulant surface favoring thrombin generation and fibrin formation. additionally , platelets express and release substances that promote tissue repair and influence processes like angiogenesis, inflammation and therefore the immune reaction . They contain large secretable pools of biologically active proteins, while newly synthesized active metabolites also are released. Although anucleate, activated platelets possess a spliceosome and may synthesize tissue factor and interleukin-1beta. The binding of secreted proteins within a developing fibrin mesh or to the extracellular matrix can create chemotactic gradients favoring the recruitment of stem cells, stimulating cell migration and differentiation, and promoting repair. [1]

Platelets in inflammation and atherogenesis

Platelets represent a crucial linkage between inflammation, thrombosis, and atherogenesis. Inflammation is characterized by interactions among platelets, leukocytes, and ECs. These interactions trigger autocrine and paracrine activation processes that cause leukocyte recruitment into the vascular wall. Platelet-induced chronic inflammatory processes at the vascular wall end in development of atherosclerotic lesions and atherothrombosis. This Review highlights the molecular machinery and inflammatory pathways employed by platelets to initiate and accelerate atherothrombosis. [2]

Platelets and cancer

The presence of platelets in association with cancer deposits has been recognised for over 100 years; however, the popularity of a two-way interaction has been newer . The link between cancer spread and platelet stimulation is pivotal to understanding of the hypercoagulable state found in most cancer patients. the help of platelets in cancer spread may provide opportunities to interrupt this relation, thus inhibiting metastasis. [3]

Functional properties of human platelets derived in vitro from CD34+ cells

The in vitro production of blood platelets for transfusion purposes is a crucial goal within the context of a sustained demand for controlled products freed from infectious, immune and inflammatory risks. The aim of this study was to characterize human platelets derived from CD34+ progenitors and to guage their hemostatic properties. These cultured platelets exhibited a typical discoid morphology despite an enlarged size and expressed normal levels of the main surface glycoproteins. They aggregated in response to ADP and a thrombin receptor agonist peptide (TRAP). After infusion into NSG mice, cultured and native platelets circulated with an identical 24 h half-life. Notably, the extent of circulating cultured platelets remained constant during the primary two hours following infusion. [4]

Platelets’ Functional Peculiarities in Persons of the Second Mature Age with Spinal Column Osteochondrosis of the Second Degree

Introduction: Many disturbances during a body are often amid some disturbance of blood parameters. Regular blood elements and, especially, platelets can play a big role in development of dystrophic changes in any tissues. Their aggregation can influence the processes of microcirculation and metabolism altogether the internals and in system . Clarification of characteristics of platelet aggregation within the second mature age which fairly often gives clinical manifestations of osteochondrosis can help in understanding the mechanisms of its progression and therefore the methods of its correction in having this disturbance patients.

The Aim: is to estimate platelets’ aggregative activity in persons of the second mature age with vertebral column osteochondrosis of the 2nd degree. [5]

Reference

[1] Nurden, A.T., Nurden, P., Sanchez, M., Andia, I. and Anitua, E., 2008. Platelets and wound healing. Frontiers in bioscience: a journal and virtual library, 13, (Web Link)

[2] Gawaz, M., Langer, H. and May, A.E., 2005. Platelets in inflammation and atherogenesis. The Journal of clinical investigation, 115(12), (Web Link)

[3] Nash, G.F., Turner, L.F., Scully, M.F. and Kakkar, A.K., 2002. Platelets and cancer. The lancet oncology, 3(7), (Web Link)

[4] Functional properties of human platelets derived in vitro from CD34+ cells
V. Do Sacramento, L. Mallo, M. Freund, A. Eckly, B. Hechler, P. Mangin, F. Lanza, C. Gachet & C. Strassel
Scientific Reports volume 10, (Web Link)

[5] Bikbulatova, A. A., Andreeva, E. G. and Medvedev, I. N. (2017) “Platelets’ Functional Peculiarities in Persons of the Second Mature Age with Spinal Column Osteochondrosis of the Second Degree”, Annual Research & Review in Biology, 21(1), (Web Link)

Leave a Reply

Your email address will not be published. Required fields are marked *