News Update on Cell Transplantation Research: Jan – 2020

Hematopoietic Stem-Cell Transplantation

Hematopoietic stem-cell transplantation, which is employed to treat both malignant and nonmalignant conditions, was first conceived quite 50 years ago, but problems related to transplanting a nonsolid organ and modulating the immune reaction had to be solved before the procedure might be used clinically. This review summarizes background information about hematopoietic stem-cell transplantation and discusses the present role of the procedure. [1]

Autologous bone-marrow stem-cell transplantation for myocardial regeneration

Implantation of bone-marrow stem cells within the heart could be a replacement method to revive tissue viability after myocardial infarct . We injected up to 1.5×106 autologous AC133+ bone-marrow cells into the infarct border zone in six patients who had had a myocardial infarct and undergone arteria coronaria bypass grafting. 3–9 months after surgery, all patients were alive and well, global left-ventricular function was enhanced in four patients, and infarct tissue perfusion had improved strikingly in five patients. We believe that implantation of AC133+ stem cells to the guts is safe and might induce angiogenesis, thus improving perfusion of the infarcted myocardium. [2]

Spermatogenesis following male germ-cell transplantation

In the man , a population of diploid stem-cell spermatogonia continuously undergoes self-renewal and produces progeny cells, which initiate the complex process of cellular differentiation that leads to mature spermatozoa. We report here that stem cells isolated from testes of donor male mice will repopulate sterile testes when injected into seminiferous tubules. Donor cell spermatogenesis in recipient testes showed normal morpholigical characteristics and produced mature spermatozoa. this system , besides opening new avenues of basic research into spermatogenesis and stem-cell self-renewal, may prove useful as a tool for life science and biotechnology. [3]

Oligodendrocyte precursor cells transplantation protects blood–brain barrier in a mouse model of brain ischemia via Wnt/β-catenin signaling

Blood–brain barrier damage may be a critical pathological feature of ischaemic stroke . Oligodendrocyte precursor cells are involved in maintaining blood–brain barrier integrity during the event . However, whether oligodendrocyte precursor cell could sustain blood–brain barrier permeability during ischemic brain injury is unknown. Here, we investigate whether oligodendrocyte precursor cell transplantation protects blood–brain barrier integrity and promotes ischaemic stroke recovery. man ICR mice (n = 68) underwent 90 min transient middle arteria cerebri occlusion. After ischemic assault, these mice received stereotactic injection of oligodendrocyte precursor cells (6 × 105). Oligodendrocyte precursor cells transplantation alleviated edema and infarct volume, and promoted neurological recovery after ischaemic stroke. [4]

Fusarium Infection after Allogeneic Stem Cell Transplantation with Prolonged Neutropenia

Fusarium is an opportunistic fungal pathogen which is emerging as a big explanation for morbidity and mortality within the immunocompromised host [1]. This disease are often localized, focally invasive or disseminated, when two or more noncontiguous sites are involved. We present a case of disseminated fusariosis during a patient with prolonged and profound neutropenia after the third allogeneic somatic cell transplantation for acute lymphocytic leukemia. [5]

Reference

[1] Copelan, E.A., 2006. Hematopoietic stem-cell transplantation. New England Journal of Medicine, 354(17), (Web Link)

[2] Stamm, C., Westphal, B., Kleine, H.D., Petzsch, M., Kittner, C., Klinge, H., Schümichen, C., Nienaber, C.A., Freund, M. and Steinhoff, G., 2003. Autologous bone-marrow stem-cell transplantation for myocardial regeneration. The Lancet, 361(9351), (Web Link)

[3] Brinster, R.L. and Zimmermann, J.W., 1994. Spermatogenesis following male germ-cell transplantation. Proceedings of the National Academy of Sciences, 91(24), (Web Link)

[4] Oligodendrocyte precursor cells transplantation protects blood–brain barrier in a mouse model of brain ischemia via Wnt/β-catenin signaling
Liping Wang, Jieli Geng, Meijie Qu, Fang Yuan, Yuyang Wang, Jiaji Pan, Yongfang Li, Yuanyuan Ma, Panting Zhou, Zhijun Zhang & Guo-Yuan Yang
Cell Death & Disease volume 11, (Web Link)

[5] Karadurmus, N., Erturk, I., Yildiz, B., Ataergin, S., Erdem, G., Gumral, R., Mert, G., Ozaydin, Şukru, Erdem, G., Gumral, R., Mert, G., Ozaydin, Şukru, Ozturk, M. and Arpaci, F. (2017) “Fusarium Infection after Allogeneic Stem Cell Transplantation with Prolonged Neutropenia”, Journal of Advances in Medicine and Medical Research, 19(11), (Web Link)

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