News Update on Liver Disease: Feb-2020

Nonalcoholic Fatty Liver Disease

Alcohol abuse is the most common cause of fatty liver disease, but it is now apparent that fat deposition in the liver, and its consequences, may occur without alcohol abuse. The principal risk factors are obesity, non-insulin-dependent diabetes mellitus, and hyperlipidemia. The disorder has a wide clinical spectrum, ranging from asymptomatic steatosis to steatohepatitis, fibrosis, and cirrhosis. This article provides a broad overview of this increasingly recognized liver disease. [1]

Association of nonalcoholic fatty liver disease with insulin resistance

BACKGROUND AND PURPOSE: Nonalcoholic fatty liver disease is frequently associated with type 2 diabetes mellitus, obesity, and dyslipidemia, but some patients have normal glucose tolerance or normal weight. [2]

A model to predict survival in patients with endstage liver disease

A recent mandate emphasizes severity of liver disease to determine priorities in allocating organs for liver transplantation and necessitates a disease severity index based on generalizable, verifiable, and easily obtained variables. The aim of the study was to examine the generalizability of a model previously created to estimate survival of patients undergoing the transjugular intrahepatic portosystemic shunt (TIPS) procedure in patient groups with a broader range of disease severity and etiology. [3]

Comparison of Doppler Echocardiographic Findings in Patients with Chronic Liver Disease with and without Intrapulmonary Shunt

Aims: Doppler echocardiography is the gold standard for the diagnosis of intrapulmonary shunt (IPS) and screening for portopulmonary hypertension in chronic liver disease (CLD). Echocardiography has become fundamental to the diagnosis of cirrhotic cardiomyopathy in the last decade. The purpose of this article was to compare echocardiographic changes in patients with CLD, with and without IPS. [4]

 Hepatitis C Virus Infection, Metabolic Disorders and Non-alcoholic Fatty Liver Disease: A Literature Review

Aims: Non-alcoholic fatty liver disease (NAFLD) is a prevalent metabolic disorder both in industrialized and developing countries that makes a large health and financial burden to the patients and the society. In the current article, we review the existing literature to find evidence for interactions between these two conditions. [5]

Reference

[1] Angulo, P., 2002. Nonalcoholic fatty liver disease. New England Journal of Medicine346(16), pp.1221-1231.

[2] Marchesini, G., Brizi, M., Morselli-Labate, A.M., Bianchi, G., Bugianesi, E., McCullough, A.J., Forlani, G. and Melchionda, N., 1999. Association of nonalcoholic fatty liver disease with insulin resistance. The American journal of medicine107(5), pp.450-455.

[3] Kamath, P.S., Wiesner, R.H., Malinchoc, M., Kremers, W., Therneau, T.M., Kosberg, C.L., D’Amico, G., Dickson, E.R. and Kim, W.R., 2001. A model to predict survival in patients with end‐stage liver disease. Hepatology33(2), pp.464-470.

[4] Mota, V.G., Markman-Filho, B., Macêdo, L.G., Becker, M.M.D.C., Edmundo, P.D.A. and Domingues, A.L.C., 2015. Comparison of Doppler Echocardiographic Findings in Patients with Chronic Liver Disease with and without Intrapulmonary Shunt. Cardiology and Angiology: An International Journal, pp.127-134

[5] Ghamar-Chehreh, M.E., Amini, M., Khedmat, H. and Taheri, S., 2015. Hepatitis C Virus Infection, Metabolic Disorders and Non-alcoholic Fatty Liver Disease: A Literature Review. Journal of Advances in Medicine and Medical Research, pp.1396-1402.

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