News Update on Cancer Immunology : March – 2020

Cancer Immunology: The Search for Specificity—G. H. A. Clowes Memorial Lecture

The major focus of cancer immunology has shifted away from arguments about the validity of the immunosurveillance theory of cancer to the more basic question of tumor-specific antigens. [1]

Cancer immunology—analysis of host and tumor factors for personalized medicine

Immune cells in the tumor microenvironment have an important role in regulating tumor progression. Therefore, stimulating immune reactions to tumors can be an attractive therapeutic and prevention strategy. [2]

From cancer genomics to cancer immunotherapy: toward second-generation tumor antigens

Clinically successful specific cancer immunotherapy depends on the identification of tumor-rejection antigens (Ags). [3]

Reviewing the Concepts of Immune Surveillance of Cancer Cells, Immunogenic Cancer Cell Death and the Role of Medicinal Plants in Anticancer Immunity

Current standard treatment of cancer usually involves surgical resection, chemotherapy and radiotherapy. Surgical resection is aimed at eliminating the primary tumour from its anatomical site of origin, while chemotherapy and radiotherapy are meant to target metastatic tumour cells around the primary tumour site and distant parts of the body. Although standard treatment of cancer usually produces some initial positive clinical responses, such responses are often followed by recurrence of malignancy, several months or years later.[4]

Evaluation of Infiltration of Immunological cells (Tumour Associated Tissue Eosinophils and Mast cells) in Oral Squamous Cell Carcinoma by Using Special Stains

Aim: Our study aimed to evaluate the infiltration of tissue eosinophils and mast cells in oral squamous cell carcinoma (OSCC) by using special stains. Study Design: Comparative study. Place of Study: Sharad Pawar Dental College, Sawangi (Meghe), Wardha, Maharashtra. [5]

Reference

[1] Old, L.J., 1981. Cancer immunology: the search for specificity—GHA Clowes Memorial lecture. Cancer research41(2), pp.361-375.

[2] Ogino, S., Galon, J., Fuchs, C.S. and Dranoff, G., 2011. Cancer immunology—analysis of host and tumor factors for personalized medicine. Nature reviews Clinical oncology8(12), p.711.

[3] Schultze, J.L. and Vonderheide, R.H., 2001. From cancer genomics to cancer immunotherapy: toward second-generation tumor antigens. Trends in immunology22(9), pp.516-523.

[4] Onoriode, O., 2018. Reviewing the Concepts of Immune Surveillance of Cancer Cells, Immunogenic Cancer Cell Death and the Role of Medicinal Plants in Anticancer Immunity. Journal of Advances in Medicine and Medical Research, pp.1-15.

[5] Debta, P., Debta, F.M., Chaudhary, M. and Dani, A., 2012. Evaluation of infiltration of immunological cells (tumour associated tissue eosinophils and mast cells) in oral squamous cell carcinoma by using special stains. Journal of Advances in Medicine and Medical Research, pp.75-85.

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