News Update on Euphorbiaceae : March – 2020

Antileukemic principles isolated from euphorbiaceae plants

Extracts of Euphorbia esula L. and Croton tiglium L., two members of the Euphorbiaceae which have been used widely in folk medicine for treating cancers, showed antileukemic activity against the P-388 lymphocytic leukemia in mice. Systematic fractionation of the extract of Euphorbia esula L. led to characterization of a major antileukemic component as the new diterpenoid diester, ingenol 3,20-dibenzoate. Similar fractionation of Croton oil led to characterization of phorbol 12-tiglate 13-decanoate as an active principle. [1]

The origin of Manihot esculenta Crantz (Euphorbiaceae)

Contrary to views that cassava (Manihot esculenta) is only known in cultivation an argument is made that wild accessions of the species grow over much of the American neotropics, in Brazil, Bolivia, Peru, Venezuela, Guyana, and Surinam. [2]

Chemical composition and antimicrobial activity of Croton urucurana Baillon (Euphorbiaceae)

In the methanolic extract of Croton urucurana Baillon (Euphorbiaceae) a number of known compounds, such as acetyl aleuritolic acid, stigmasterol, β-sitosterol, campesterol, β-sitosterol-O-glucoside, sonderianin, catechin and gallocatechin were isolated and identified by MS and NMR spectroscopy, HRGC and data from literature. [3]

Ovicidal and Larvicidal Effects of Ricinus communis L. (Euphorbiaceae) Extracts on Phlebotomus duboscqi

Aims: To evaluate the Ovicidal and larvicidal effects of Ricinus communis (Euphorbiaceae) extracts on Phlebotomus duboscqi.

Study Design: A comparative experimental design using extracts obtained from the leaf and bark of Ricinus communis plant. [4]

Isolation and Chemical Structural Characterization of the Mixture of Two Related Phytosterols from Ricinus communis L. (Euphorbiaceae) Leaves

Aim: Ricinus communis, a member of the family Euphorbiaceace, is widely used in South African traditional medicine for the treatment of wounds, sores and boils. The plant was selected based on a high antibacterial activity demonstrated in a previous In vitro study. There is a need to isolate compounds that are responsible for antibacterial activity of R. communis leaves. [5]

Reference

[1] Kupchan, S.M., Uchida, I., Branfman, A.R., Dailey, R.G. and Fei, B.Y., 1976. Antileukemic principles isolated from Euphorbiaceae plants. Science191(4227), pp.571-572.

[2] Allem, A.C., 1994. the origin of Manihot esculenta crantz (Euphorbiaceae). Genetic resources and crop Evolution41(3), pp.133-150.

[3] Peres, M.T., Delle Monache, F., Cruz, A.B., Pizzolatti, M.G. and Yunes, R.A., 1997. Chemical composition and antimicrobial activity of Croton urucurana Baillon (Euphorbiaceae). Journal of ethnopharmacology56(3), pp.223-226.

[4] are Samuel, M., Zipporah, N., Philip, N., Ingonga, J. and Peter, N. (2015) “Ovicidal and Larvicidal Effects of Ricinus communis L. (Euphorbiaceae) Extracts on Phlebotomus duboscqi”, European Journal of Medicinal Plants, 11(3), pp. 1-14. doi: 10.9734/EJMP/2016/22241.

[5] Masoko, P. and Nemudzivhadi, V. (2015) “Isolation and Chemical Structural Characterization of the Mixture of Two Related Phytosterols from Ricinus communis L. (Euphorbiaceae) Leaves”, European Journal of Medicinal Plants, 10(2), pp. 1-11. doi: 10.9734/EJMP/2015/18172.

 

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