The current research work aims to synthesise some new sequence of quinazoline-4-one/4-thione derivatives by changing structures that preserve the fundamental structural characteristics of biological activity and screening various experimental animal models for their anti-anxiety activity. A sequence of derivatives of 7-chloro-3-[substituted (amino/phenyl amino)]-2-phenyl quinazoline-4(3H)-one/thione and 1-(7-chloro-4-oxo/-2-phenylquinazoline-3-(4H-yl))-substituted urea were prepared and characterised from various spectra and elemental analyses. Elevated plus maze test, hole board test, respectively, examined the anti-anxiety behaviour. The synthesis of the quinazoline derivatives was verified by physico-chemical and spectroscopic data. Compared to diazepam, five compounds (IIg, IIj, IIIg, IIIh and IIIj) demonstrated strong anti-anxiety activity and showed no neurotoxicity in the rotarod procedure. The quinazoline derivatives obtained indicate that the methyl/methoxy group is important for anti-anxiety activity in the phenyl hydrazine ring, amine, urea and thiourea replacement at the 3rd position of the quinzoline ring. A further study of the newly synthesised and pharmacologically active quinazoline molecules is being performed in vitro.
Author (s) Details
Dr. Biswajit Dash
NEPEDS College of Pharmaceutical Sciences, Guwahati, Assam, 781028, India.
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