Advanced Study on Salivary Progesterone as a Biomarker in Pregnancy

Progesterone is considered a hormone for pregnancy. At the end of labor, progesterone was measured in the saliva of pregnant females. During the last two weeks before the planned delivery date and 2 days after delivery, samples were collected twice a day (morning and afternoon). Using commercial ELISA kits, analysis was performed after basic freezing, thawing and centrifugation of the samples. It appeared that the progesterone level was in a steady state during the time before delivery, until around 2 days prior to delivery, at which point a rapid decrease could be observed. The amounts decreased to non-pregnant values again immediately after delivery. Two separate ELISA kits were used for comparative purposes and tested for suitability. Furthermore, the applicability and usefulness of the additional salivary estriol determination was investigated in a preliminary experiment. In conclusion, salivary progesterone can be used in pregnant women as an indication of imminent delivery. An additional parameter supporting the efficacy of salivary progesterone could be salivary estriol. Estriol is also considered to provide information about the well-being of the fetus and is said to be a catalyst for delivery. As a consequence, its study can also help to predict the time of delivery, to take optional steps in the case of premature delivery or difficult pregnancies, and to provide information on fetal health. In order to statistically test the results of this study by adding more participants, both having normal deliveries and complicated pregnancies, additional research is required. The findings of this study are intended only to suggest the possibility of creating a home-use biosensor that would contribute significantly to the health of mothers and newborns.

Author (s) Details

Dr. P. Meulenberg Eline
ELTI Support VOF, Ambachtsweg 5, 6581 AX Malden, The Netherlands.

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