In vivo Anti-inflammatory and Anti-osteoarthritis Effects of a Vietnamese Traditional Remedy, KNC, in Animal Models

In Vietnam Traditional Medicine, the KNC treatment contains 14 herbs and has been used to treat rheumatism. However, specifics have been documented in the KNC anti-inflammatory and anti-osteoarthritis studies so far. The goal of this study was to investigate in vivo the antinociceptive and anti-inflammatory effects of an aqueous extract of the conventional Vietnamese formulation KNC in experimental animal models of nociception and inflammation. Anti-inflammatory activity was demonstrated by the KNC extract, which significantly decreased the production of carrageenan-induced oedema and granuloma. The anti-OA effects of KNC resulted in substantial hind limb weight-bearing recovery, serum cytokine output inhibition, including tumor necrosis factor (TNF)-a, interleukin (IL)-1b, IL-6, prostaglandin E2 (PGE2) and inhibition of knee damage and synovial hyperplasia in rat OA models. Therefore, in Wistar rats, KNC extract demonstrated anti-inflammatory and anti-OA activity.

Author (s) Details

Xuan Canh Dau
Vietnam University of Traditional Medicine, 2 Tran Phu Street, Mo Lao Ward, Ha Dong District, Hanoi 12110, Vietnam.

Thi Ngoc Nguyen
Vietnam University of Traditional Medicine, 2 Tran Phu Street, Mo Lao Ward, Ha Dong district, Hanoi 12110, Vietnam.

Manh Hung Tran
Faculty of Pharmacy, Dong A University, 33 Xo Viet Nghe Tinh, Hoa Cuong Nam ward, Hai Chau District, Da Nang City 550000, Vietnam.

Hoang Ngan Nguyen
Vietnam Military Medical University, 160 Phung Hung Street, Phuc La Ward, Ha Dong District, Hanoi 12108, Vietnam.

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