Lycopodium Alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis and Their Anti-cholinesterase Activity

Vietnamese Huperzia squarrosa was isolated from a sequence of lycopodium alkaloids, namely lycosquarosine A (1), acetylaposerratinine (2), huperzine A (3), huperzine B (4), 8pha-hydrophlemariurine B (5) and huperzinine (6). Among them, the latest natural source metabolite is lycosquarosine A (1). Dose-dependent AChE activity was completely inhibited by lycosquarosine A with an IC50 value of 54.3 μg/mL, while acetylposerratinine (2) displayed greater inhibitory activity than 1 with an IC50 value of 15.2 μg/mL. This outcome suggests that AChE inhibitors may be a potent source of these alkaloids. This is the first paper on H’s alkaloid constituents. Vietnamese squarrosa and the possible inhibitory activity of cholinesterase in these compounds may indicate new sources of anti-disease Alzheimer’s agents.

Author (s) Details

Nguyen Ngoc Chuong
Faculty of Traditional Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, 217 Hong Bang Street, Ward 11, District 5, Ho Chi Minh City 72200, Vietnam.

Tran Cong Luan
Faculty of Pharmacy and Nurse, Tay Do University, 68 Tran Chien Street, Le Binh Ward, Cai Rang District, Can Tho City 94100, Vietnam.

Manh Hung Tran
Faculty of Pharmacy, Dong A University, 33 Xo Viet Nghe Tinh, Hoa Cuong Nam Ward, Hai Chau District, Da Nang City 550000, Vietnam.

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