Pimarane Diterpenes from Vietnamese Orthosiphon stamineus Benth. and Their Glucose Uptake Stimulatory and PTP1B Inhibitory Activities

From Orthosiphon stamineus Benth, seven pimarane diterpenes (1–7) have been isolated. By isolation by assay-guided. Both isolates had a 2-deoxy-2-((7-nitro-2,1,3-benzoxadiazole-4-yl)amino)-d-glucose absorption effect at 5 and 10 μM concentrations in 3T3-L1 adipocytes. Most of them demonstrated potent protein tyrosine phosphatase 1B inhibition with IC50 values ranging from 0.33 to 9.84 μM. In the kinetic analysis, all forms of inhibition were exposed to the forces studied, including mixed-competitive (1), non-competitive (3 and 5), competitive (6) and non-competitive (6) powers (7). The findings have indicated that O. Stamineus and its pimarane diterpenes could exert the hypoglycemic effect via the pathway of insulin signaling targeting protein tyrosine phosphatase 1B (PTP1B) activity inhibition. The findings indicate that these active constituents of O. Stamineus is a possible natural product for the production of antihypoglycemic agents.

Author (s) Details

Phi Hung Nguyen
Department of Chemical Analysis, Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi 122100, Vietnam and Faculty of Chemistry, Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi 122100, Vietnam.

Dao Cuong To
Faculty of Pharmacy, Phenikaa University, Yen Nghia, Ha Dong, Hanoi 12116, Vietnam and Phenikaa Research and Technology Institute (PRATI), A&A Green Phoenix Group JSC, No.167 Hoang Ngan, Trung Hoa, Cau Giay, Hanoi 11313, Vietnam.

Manh Hung Tran
Faculty of Pharmacy, Dong A University, 33 Xo Viet Nghe Tinh, Hoa Cuong Nam ward, Hai Chau district, Da Nang city 550000, Vietnam.

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