Antimicrobial Activity of Newly Synthesized Thiabendazoles

In the present research, three new thiabendazole derivatives (4b and 6a-c) and their intermediates (3a-b) were synthesized in moderate to good yields by the reaction of low-cost, readily accessible amines with 4-cyanothiazole. For all the compounds (3a-b, 4b and 6a-c), preliminary in vitro antimicrobial assessment was performed using the whole cell growth inhibition assay method for Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa, Candida albicans and Cryptococcus neoformansvar. Our research efforts identified the highly potent antibacterial agent 3b that showed good growth inhibition (77.12 percent) against Acinetobacter baumannii gram-negative bacteria.

Author (s) Details

Dr. Siddappa A. Patil
Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Kanakapura, Ramanagaram, Bangalore 562112, India.

Mr.  Vikrant Patil
Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Kanakapura, Ramanagaram, Bangalore 562112, India.

Dr. Renukadevi Patil
Pharmaceutical Sciences Department, College of Pharmacy, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA.

Dr. Alejandro Bugarin
Department of Chemistry and Physics, Florida Gulf Coast University, Fort Myers, FL 33965, USA.

Dr. Shivaputra A. Patil
Pharmaceutical Sciences Department, College of Pharmacy, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA.

View Book :- https://stm.bookpi.org/CACB-V2/issue/view/16

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