Advanced Studies on Anticoagulant Activity and Molecular Docking of 7,9-bis(4-Chlorophenyl)- 6-methyl-1,4-dioxa-8-azaspiro[4.5]decane through Target Protein Thrombin

One of the relevant requirements for their biological activities is the asymmetrical point of the molecules because of the chiral spiro carbon. There are possible biological properties of Spiro compounds. The present study documented the synthesis and anticoagulant activity of spiro compounds and the potential compound was subjected to bioinformatics tools to study their binding mode and interaction. Among the five compounds studied, decane 7,9-bis(4-chlorophenyl)-6-methyl-1,4,8-triaza spiro[4.5] has prolonged activated partial thromboplastin time at 25 μg mL-1, respectively, and prothrombin time at 22.7s and 18.5s. The mandatory way of researching this compound was therefore carried out using the bioinformatics method. Among the five compounds, compound 9 against activated partial thromboplastin time and prothrombin time assay was classified as a potent anticoagulant (25 μg mL-1). The results of the interaction show that this compound binds to the target protein thrombin active site, which is close to that of the current inhibitor and could in future also be considered as an anticoagulant drug.

Author (s) Details

Dr. N. Manivannan
Department of Chemistry, Ramakrishna Mission Vivekananda College (Autonomous), Mylapore, Chennai-600004, India.

Dr. B. Elanchezhian
Department of Chemistry, AVC College (Autonomous), Mannampandal, Myladuthurai-609305, India.

Dr. G. Selvanathan
Department of Chemistry, AVC College (Autonomous), Mannampandal, Myladuthurai-609305, India.

Dr. S. Sugunakala
Department of Bio-Informatics, AVC College (Autonomous), Mannampandal, Myladuthurai-609305, India.

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