Study on Asymmetric Hydrogenation of N-heterocycles with Sodium Cyanoborohydride and S – (-) – Binol

Hydrogenation is the easiest but most efficient way to use cheap, safe hydrogen gas without forming any waste to manufacture a wide variety of essential compounds in large quantities. Indole-3-aldehyde, indazole-3-aldehyde and aza indole-3-aldehyde asymmetric hydrogenation with sodium cyanoborohydride and s-binol under glac. Acetic acid gave enantiomeric excess of 3-substituted 2,3-dihydro alcohols at good yields over a period of 1-2 h. This is the first research on the hydrogenation of aromatic compounds such as indoles, indazoles and aza indoles with Sodium cyanoborohyddride, a mild decreasing catalyst.

Author (s) Details

Reddymasu Sreenivasulua
Department of Chemistry, University College of Engineering (Autonomous), Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh, 533003, India.

Rudraraju Ramesh Rajub
Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Andhra Pradesh, 522510, India.

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