Recent Study on Synthesis of Novel Series of Quinolino [3,2-f][1,2,4] triazolo [3,4-b][1,3,4] Thiadiazepines Derivatives Incorporated with 3-(5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl) Moiety as Potent Antimicrobial Agent

A Quinolino novel series[3,2-f] [1,2,4] The [3,4-b] Triazolo [1,3,4] The Thiadiazepine (7a-i) derivatives incorporated with 3-(5–i) (benzofuran-2-yl) -1-phenyl-1H-3-yl pyrazol) Moiety was synthesised by a 5-(5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl)) one-point cyclo-condensation reaction. -4-amino-4H-1,2,4-triazole-3-thiol (4) in the presence of K2CO3 in DMF with 2-chloro-quinoline-3-carbaldehyde derivatives (6a-i). Characterization of 3-(5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl)-substituted quinolino [3,2-f] newly synthesised compounds [1,2,4] triazolo[3,4-b] triazolo Elemental analysis and spectral studies such as FT-IR, 1H NMR and 13C NMR, further assisted by Mass Spectra, have been performed with[1,3,4]thiadiazepines. Both synthesised compounds were tested in vitro against the pathogenic microorganism bacterial strains, S. aureus E.coli, P.vulgaris, S.typhi at different concentrations for their antimicrobial activities. In comparison with Chloramphenicol, the bioassay outcome suggested strong to moderate activity against these microbial strains. Through cyclocondensation of 5-(5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl)-4-amino-4H-1,2,4-triazole-3-thiol with 2-chloro-quinoline-3-carbaldehyde derivatives in DMF as a solvent, 1,3,4-thiadiazepine derivatives have been synthesised by economic, better yield and safer methods. Physical, analytical and spectral data established their purity and confirmation. The antimicrobial screening of compounds 7a-f was investigated and it was found that these compounds had excellent to moderate activity against selected strains of bacteria.

Author (s) Details

Dr. M. Idrees
Department of Chemistry, Government Institute of Science, Nagpur (M.S.), 440001, India.

Dr. S. Kola
Department of Chemistry, Government Science College, Gadchiroli (M.S.), 442 605, India.

Dr. N. J. Siddiqui
Department of Chemistry, Government Institute of Science, Nagpur (M.S.), 440001, India.

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