A Review on Brown Seaweed Fucoidan in Cancer: Implications in Metastasis and Drug Resistance

Brown seaweed and marine invertebrates contain fucoidans, which are sulphated polysaccharides. They have anti-cancer properties because they target several signalling channels and molecular processes in cancerous cells. The chemical structure diversity of fucoidans, as well as their similarities to other molecules such as glycosaminoglycan, are defined in this study, allowing them to participate in a variety of biological processes. This analysis also summarises their effect on the production of metastasis and drug resistance, which are the two most important barriers to cancer cure. Fucoidans have been shown to inhibit the processes of EMT, migration, invasion, and metastasis in certain cancer forms. Finally, this article explores how fucoidans have been studied in clinical trials to see whether they have a synergistic impact with other anti-cancer medications.

Author (s) Details

María Elena Reyes
Laboratory of Integrative Biology (LIBi), Center of Excellence in Translational Medicine- Scientific and Technological Bioresource Nucleus (CEMT-BIOREN), Universidad de La Frontera, Temuco 4710296, Chile.

Dr. Ismael Riquelme
Instituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Temuco 4810101, Chile.

Tomás Salvo
Laboratory of Integrative Biology (LIBi), Center of Excellence in Translational Medicine- Scientific and Technological Bioresource Nucleus (CEMT-BIOREN), Universidad de La Frontera, Temuco 4710296, Chile.

Louise Zanella
Laboratory of Integrative Biology (LIBi), Center of Excellence in Translational Medicine- Scientific and Technological Bioresource Nucleus (CEMT-BIOREN), Universidad de La Frontera, Temuco 4710296, Chile.

Dr. Pablo Letelier
Precision Health Research Laboratory, Departamento de Procesos Diagnósticos y Evaluación, Facultad Ciencias de la Salud, Universidad Católica de Temuco, Temuco 4813302, Chile.

Dr. Priscilla Brebi
Laboratory of Integrative Biology (LIBi), Center of Excellence in Translational Medicine- Scientific and Technological Bioresource Nucleus (CEMT-BIOREN), Universidad de La Frontera, Temuco 4710296, Chile.

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