Nested Variant of Urothelial Carcinoma: A Review and Update of the Literature

Background: In 2004, the World Health Organization classified Nested Variant of Urothelial Carcinoma as a new variant.

The aim of this study was to conduct a literature review on the nested variant of urothelial carcinoma.

The following are the outcomes: So far, about 200 cases of Nested variant urothelial carcinoma have been identified, with the tumour exhibiting the following morphological characteristics: The lamina propria and the muscularis propria are infiltrated by large numbers of small confluent irregular nests of bland-appearing, tightly packed, haphazardly organised, poorly defined urothelial cells.

Because of its bland appearance, the tumour has been misdiagnosed as a benign lesion on occasion, causing a substantial delay in determining the correct diagnosis and leading to the disease’s advanced stage.

The tumour shares certain immunohistochemical characteristics with high-risk traditional urothelial carcinomas, such as a high proliferation index and the loss of p27 expression. Immunoreactivity to p53, bcl-2, or EGF-r, on the other hand, is rare.

The tumour must be distinguished from a variety of urothelial proliferative lesions.

Conclusions: A correct and early diagnosis of this tumour is critical for providing early curative care and avoiding a diagnosis at a later point. To find treatment options that will improve the outcome of this tumour, a multi-center trial is required.

Author (s) Details

Anthony Kodzo-Grey Venyo
Department of Urology, North Manchester General Hospital, Delaunays Road, Manchester, United Kingdom.

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