Putrescine, spermidine, and spermine are polyamines that occur naturally in living organisms. They can be found in tissues and fluids of mammals. They communicate with a number of polyanions, including nucleic acids, since they are simple molecules. Polyamines help to keep deoxyribonucleic acid stable. Their function in diabetes mellitus and reproductive disorders, not only in male but also in female reproduction, has recently gotten a lot of attention. Several studies have shown that sperm deoxyribonucleic acid is glycated and fragmented in uncontrolled diabetic males, which has implications for human reproduction. Polyamines are shown to inhibit both processes in our lab. This paper discusses the production, interconversion, and physiological effects of polyamines in sperm cells, with a focus on human sperm cells.
Author (s) Details
José D. Méndez
Medical Research Unit in Metabolic Diseases, Cardiology Hospital, National Medical Center, Mexican Institute of Social Security, P.O.Box A-047, 06703 Mexico City, Mexico.
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