Documenting Mast Cell Infiltration and Leukotriene Receptor Expression in Various Tumors: Possible Clinical Application of Common Pathological Findings Concerned with Tumor Development

Since the mechanisms underlying tumour growth are unknown, it is critical to identify and treat tumours early in order to save patients with malignant tumours. Surgery, chemotherapy, and radiotherapy are the latest treatments available to patients. However, several patients are unable to be rescued by such treatments. In certain cases of a suspected benign tumour, the best course of action is to simply monitor its progress before removing it surgically if possible. Using experimental rats with random tumours, we discovered the common features of different tumour tissues and demonstrated the effect of therapeutics that target them. The light and electron microscopes were used to analyse 26 different types of human tumours (epithelial or mesenchymal origin, malignant or benign), as well as Sprague-Dawley rats with spontaneous mammary gland tumours. Toluidine blue staining and immunohistochemical staining were used to identify mast cells and leukotriene receptors. One of the leukotriene receptor antagonists was given to the rats orally. The presence of multiple mast cells and the expression of leukotriene receptors in different tumours were discovered (human tumours and rat spontaneous tumors). And the therapeutic effects of leukotriene receptor antagonist administration on rat tumours, which blocked not only tumour progression but also angiogenesis and nerve development. Early detection and treatment of malignant tumours will be a more successful way of saving patients with such tumours. Our findings indicate that allergic reactions, in which leukotriene and leukotriene receptors tend to play a key role, may be involved in the development and progression of tumours, and that controlling such reactions may be a way to slow tumour progression. Our findings could be useful in oncology clinical applications.

Author (s) Details

Masao Sugamata
Department of Pathology, Tochigi Institute of Clinical Pathology, Tochigi, Japan.

Tomomi Ihara
Department of Pathology, Tochigi Institute of Clinical Pathology, Tochigi, Japan.

Miho Sugamata
Department of Pathology, Tochigi Institute of Clinical Pathology, Tochigi, Japan.

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