Despite the fact that life began in anoxia, many species came to rely on oxygen for survival, developing independently complex respiratory systems to remove CO2 and acquire oxygen from the atmosphere. As a result, Oxygen, both a vital gas and a deadly poison, constitutes a trade-off in which all species have struggled. Life cannot exist without oxygen. Inhaled oxygen is absorbed into the bloodstream; dissolved oxygen combines with food (which is stored in the body as sugars) to provide energy and heat – metabolism. Since centuries, the study of oxygen movements in the tissues of the human body has piqued people’s interest. Dr. Christian Bohr and August Krogh worked on respiratory physiology and capillary modelling at the turn of the century, using mathematical models to measure molecular transport in microcirculation and attempting to assess the negative effects of a lack of oxygen transport to tissues. Computer simulation, it was said, allowed for the investigation of the systems’ dynamic and nonlinear characteristics. However, the findings have been and continue to be conflicting. Dietrich Werner Lubbers (1917-2005) received several patents in Germany for designs related to the analysis of gases in tissues. Dietrich Lübbers’ goal in his research was to figure out the whole pathway and control of oxygen transfer from the blood into the mitochondria. Under physiological conditions, analysis of pO2 histograms on most organs showed a striking similarity: a Gaussian distribution of less than 5% of values less than 5mmHg. Other research used near infrared spectroscopy (NIRS) to detect changes in the concentrations of oxy- ([HbO2]), deoxy- ([HHb]), and complete haemoglobin ([HbT]=[HbO2] [HHb]) . Diabetic rats’ kidney oxygen supply was found to be significantly reduced, presumably due to increased oxygen consumption .
Author (s) Details
Arturo Solís Herrera
Centre of Studies in Photosynthesis in Humans, Aguascalientes 20000, México.
Oscar Aguilera Madrigal
Instituto Mexicano del Seguro Social, México.
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