Postprandial Effects of a Proprietary Milk Protein Hydrolysate Containing Bioactive Peptides in Prediabetic Subjects: A Recent Study

Milk proteins are thought to protect against type 2 diabetes (T2DM) through regulating the glycemic response, particularly in the postprandial state. The high content of whey proteins, which are usually a byproduct of cheese production, is one reason for this possibility. Milk contains two protein fractions: casein, which is slowly digesting, and whey, which is quickly digestible. However, because of its increased leucine content, native whey has gotten a lot of attention, and its postprandial glycemic effect in prediabetes has yet to be determined. In this study, prediabetics were given a randomised, cross-over trial to see how effective a milk protein hydrolysate of native whey origin with alpha-glucosidase inhibitory capabilities was. Prior to a high-carbohydrate challenge meal, subjects were given a single dosage of placebo, low-dosed milk protein hydrolysate, or high-dosed milk protein hydrolysate. Glucose and insulin concentration-time curves were examined. Low-dosed milk peptides significantly reduced incremental areas under the curve (iAUC) of glucose as the primary endpoint compared to placebo (P = 0.0472), and a slight insulinotropic effect was observed. A longer intervention period with the low-dosed product did not improve glucose response but did reduce HbA1c levels significantly (P = 0.0244). To summarise, the current milk protein hydrolysate of native whey origin has the potential to modify postprandial hyperglycemia and hence may help to reduce the risk of developing T2DM in the future.

Author(s) Details

Tina Sartorius
BioTeSys GmbH, Division Clinical Studies, Esslingen, Germany.

Andrea Weidner
BioTeSys GmbH, Schelztorstr. 54–56, 73728 Esslingen, Germany.

Tanita Dharsono
BioTeSys GmbH, Schelztorstr. 54–56, 73728 Esslingen, Germany.

Audrey Boulier
Ingredia S.A., 51 Avenue F. Lobbedez CS 60946, 62033 Arras CEDEX, France.

Manfred Wilhelm
Department of Mathematics, Natural and Economic Sciences, Ulm University of Applied Sciences, Albert-Einstein-Allee 55, 89081 Ulm, Germany.

Christiane Schön
BioTeSys GmbH, Schelztorstr. 54–56, 73728 Esslingen, Germany.

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