Soluble Receptor for Advanced Glycation End Products (sRAGE) Variation in Human Papilloma Virus (HPV) Infection – The Role of the AGEs-sRAGE Axis in Evaluating the Oxidative Stress

Human papillomavirus (HPV) affects the skin’s keratinocytes and mucous membranes, resulting in a number of diseases. The most frequent HPV-related lesions are cutaneous and genital warts. Oxidative stress has been implicated as a cofactor in HPV pathogenesis in recent research. The link between the accumulation of advanced glycation end products (AGEs) and the development of HPV-related mucocutaneous lesions has yet to be established. In individuals with HPV-related cutaneous lesions, we looked into the role of the AGEs-sRAGE axis. The study comprised 41 patients with warts (26 patients with palmoplantar warts and 15 patients with genital warts) and 28 healthy people as controls. Using the ELISA approach, we were able to measure the serum levels of AGEs and the circulating soluble receptor for AGEs (sRAGE). When compared to the control group, sRAGE levels were lower in individuals with palmoplantar warts (p0.05) and genital warts (p>0.05). Although there was no statistical significance, we discovered greater levels of AGEs in individuals with HPV-related cutaneous lesions compared to controls. In patients with palmoplantar warts (r=-0.43, p0.02) and genital warts (r=-0.47, p>0.05), we found a negative connection between sRAGE and AGEs. Our findings show that the AGEs-sRAGE axis may play a role in HPV infection pathogenesis, and that modulating it could have therapeutic benefits.

Author(s) Details

Mircea Tampa
Department of Dermatology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania and “Victor Babes” Clinical Hospital for Infectious Diseases, 030303 Bucharest, Romania.

Ilinca Nicolae
“Victor Babes” Clinical Hospital for Infectious Diseases, 030303 Bucharest, Romania.

Cristina Iulia Mitran
Department of Microbiology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Madalina Irina Mitran
Department of Microbiology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Clara Matei
Department of Dermatology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Corina Daniela Ene
”Carol Davila” Nephrology Hospital, 010731 Bucharest, Romania.

Simona Roxana Georgescu
Department of Dermatology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania and “Victor Babes” Clinical Hospital for Infectious Diseases, 030303 Bucharest, Romania.

Mircea Ioan Popa
Department of Microbiology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania and “Cantacuzino” National Medico-Military Institute for Research and Development, 011233 Bucharest, Romania.

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