Study of Craniorachischisis, with Emphasis on Prenatal Diagnosis and Prevention

The first paragraph is an introduction. Malformations of the central nervous system (CNS) make up a significant fraction of all congenital anomalies, second only to heart malformations. Exencephaly is the failure of the cephalic and caudal halves of the neural tube to fuse, while Spina bifida is the failure of the caudal section of the neural tube to fuse.

The goal of this research was to gain a better knowledge of Craniorachischisis, a condition marked by anencephaly and open spina bifida. Congenital cracks in the skull and spinal column were also connected to it. This is the most serious type of NTD, and new research suggests that taking folic acid before conception reduces the risk of NTDs by 50-70 percent. As a result, the focus was on prenatal diagnosis and prevention.

Methods and Results: In order to better understand Craniorachischischisis, the current study covers 1000 live births as well as 100 stillborn foetuses and abortuses. The Obstetrics and Gynecology department sent two unclaimed foetuses, one with Craniorachischisis totalis and the other with Craniorachischisis with omphalocele. There was no information about the patient’s family or obstetric history available.

The failure of mesoderm and neuroectoderm development causes neural tube defects (NTDs), which are embryonic induction disorders. A number of writers were inspired to launch a series of clinical investigations after learning that periconceptional folic acid supplementation reduced NTDs by 50-70 percent.

Finally, the majority of NTDs are sporadic, with genetic and non-genetic environmental factors both contributing to their pathogenesis.

Author(s) Details

Gayathri Pandurangam
Department of Respiratory Care, College of Applied Medical Sciences in Jubail, Imam Abdulrahman bin Faisal University, Saudi Arabia.

S. Saritha
Department of Anatomy, KAMSRC, Hyderabad, India.

D. Nagajyothi
Department of Anatomy, Government Medical College, Nalgonda, Telangana, India.

T. V. Ramani
Department of Anatomy, Bhaskar Medical College, Hyderabad, India.

N. Himabindu
Department of Anatomy, KAMSRC, Hyderabad, India.

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