Prevalence of Extended-Spectrum β-Lactamases Producing Klebsiella pneumoniae Isolates: A Case from Tertiary Care Hospital, South India

The importance of Klebsiella in the rising frequency of gram-negative aerobic bacillary nosocomial infections in the US and India. In this antibiotic era, antimicrobial resistance is on the rise, which is a major source of concern. One of the most common causes of sepsis and infection-related mortality is multidrug-resistant bacteria like Klebsiella pneumoniae. The goal of this study was to determine the prevalence of ESBL-producing Klebsiella in various clinical specimens using phenotypic approaches. Materials and Procedures: In a prospective laboratory-based analysis, the presence of Extended Spectrum—lactamases (ESBLs) in samples obtained over a two-year period was confirmed phenotypically. Over the course of two years, 7644 gram negative bacterial isolates were obtained from a total of 16526 clinical specimens received at the microbiology lab. 1157 of the 2497 Klebsiella isolates tested positive for ESBL (46 percent ). Conclusion: Drug-resistant Klebsiella infections that produce ESBL are difficult to treat and can be deadly. A robust and rapid implementation of an effective antibiotic policy, as well as the sensible use of antibiotics, is required in all healthcare settings.

Author (s) Details

Rangnekar Aseem
Department of Microbiology, AIIMS, Raebareli, India.

Mallaya Shrikara
Department of Microbiology, AIIMS, Raebareli, India.

Shenoy Shalini
Department of Microbiology, AIIMS, Raebareli, India.

Gupta Shefali
Department of Microbiology, AIIMS, Raebareli, India.

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