Influence of Abnormal Thyroid Hormone Changes on Lipid Peroxidation and Antioxidant Imbalance in Hypothyroid and Hyperthyroid Patients

The thyroid gland is the body’s main metabolic regulator. Normal organ development necessitates thyroid hormones. Thyroid hormones in high doses have been shown to change oxygen metabolism in cells and accelerate the formation of free radicals. When compared to normal and hypothyroidism, thyroid hormone has a pro-oxidant action and increases the generation of oxygen free radicals, resulting in a drop in antioxidant status in hyperthyroidism. Oxidative stress is also caused by thyroxin administration. Oxidative stress and hypothyroidism both impair the immune system. The thyroid gland appears to play a key role in the generation of widespread oxidative stress in pathological states. Thyroid hormones are essential regulators of mitochondrial oxidative metabolism. The goal of this research is to examine at free radical scavenging activity, lipid peroxidation, and other related topics. and antioxidant levels in hyperthyroidism and hypothyroidism patients In conclusion, our findings imply that individuals with hypothyroidism and hyperthyroidism have a high generation of ROS and oxidative stress, as well as increased lipid peroxidation and a failure of antioxidant defence mechanisms.

Author(s) Details

Babu Kandasamy
Department of Biochemistry, Kongunadu Arts and Science College, G. N. Mills, Coimbatore, Tamil Nadu, India.

Indira A. Jayaraaj
Department of Biochemistry, Kongunadu Arts and Science College, G. N. Mills, Coimbatore, Tamil Nadu, India.

Jeganathan Prabhakar
J. P. Thyroid Clinic, Coimbatore, Tamilnadu, India.

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