Trends in Evolution of Anthelminthic Chemical Agents: Ecological, Physiological and Biochemical Adaptation in Helminth
In this study, the key anthelminthic compounds are discussed, including alternative medicine components, different types of pluripotent manufactured and naturally occurring compounds. The sections devoted to recent discoveries (Emodepside, Monepantel, Derquantel, Tribendimidine) and certain promising efforts receive a lot of attention. The overview also covers molecular mechanisms of action of anthelminthic substances, helminth adaptation to anthelminthic chemicals, and alternative worming therapies. Synthetic non-organic and organic or natural compounds are used as antihelminthic agents. The hypothesis on the viability of the targeted search for such compounds among the derivatives of conditionally progenitor cyclic hydrocarbons – benzene, indene, naphthalene, 1H-cyclopenth [a]-naphthalene, and phenanthrene – by alternating absolutely unsaturated and saturated structures, is based on a systemic analysis of particular features of the chemical structure of anthelminthic substances.
Author (s) Details
M. Kh. Dzhafarov
K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology, 109472 Moscow, ul. Akademika Skryabina, Russia.
F. I. Vasilevich
K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology, 109472 Moscow, ul. Akademika Skryabina, Russia.
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