Bio-applications of Bacterial Cellulose and Type ICollagen Conjugated with Resveratrol for Epithelial Defect Regeneration

Effective wound repair and regeneration require excellent wound dressing. The purpose of this chapter is to assess the efficacy of bacterial cellulose (BC) and type I collagen (COL) scaffolds conjugated with resveratrol (RSV) in wound management. BC and COL are biodegradable and renewable polymers with a strong affinity for materials containing hydroxyl groups, whereas RSV has a 4′-hydroxyl group and exhibits good biocompatibility and no cytotoxicity. The results showed that RSV was effectively released in vitro from the BC and COL scaffolds, and immunofluorescence staining revealed that both scaffolds were present. Epithelia that has been regenerated and is highly biocompatible. Furthermore, Masson’s trichrome staining revealed that both scaffolds preserved the normal collagen-bundling pattern and stimulated re-epithelialization in defective rat epidermis. These findings suggest that RSV-conjugated BC or COL scaffolds provided a biocompatible environment for stem cell attachment and growth, as well as promoting epithelial regeneration during wound healing.

Author (s) Details

Juin-Hong Cherng
Department and Graduate Institute of Biology and Anatomy, National Defense Medical Center, 114 Taipei, Taiwan, R.O.C. Department of Gerontological Health Care, National Taipei University of Nursing and Health Sciences, 112 Taipei, Taiwan, R.O.C.

Shu-Jen Chang
Division of Rheumatology/Immunology/Allergy, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, 114 Taipei, Taiwan, R.O.C.

Dewi Sartika
Laboratory of Adult Stem Cell and Tissue Regeneration, National Defense Medical Center, 114 Taipei, Taiwan, R.O.C.

Cheng-Che Liu
Department of Physiology and Biophysics, Graduate Institute of Physiology, National Defense Medical Center, 114 Taipei, Taiwan, R.O.C.

Sheng-Tang Wu
Division of Urology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, 112 Taipei, Taiwan, R.O.C.

En Meng
Division of Urology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, 112 Taipei, Taiwan, R.O.C.

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