Study on Synthesis and Characterization of New 8- Trifluloromethyl Quinazolin-2,4-(3H)-Dione Nucleosides

The synthesis of 8-trifluloromethyl quinazolin-2,4-(1H,3H)-dione 2, which was ribosylated by coupling with 1-O-acetyl-2,3,5-tri-O-benzoyl—D-ribofuranose 4 via the silylation method, yielded mixture and -anomeric benzoylated nucleoside derivatives 5 and 6, respectively. As part of our ongoing interest in the synthesis of new nucleosides with expected biological activity, quinazolin-2,4-(3H)-dione nucleosides containing trifluloromethyl group were designed in this review. Debenzoylation of 5 and 6 in dry methanol by sodium metal yields the corresponding free nucleosides 7 and 8, respectively.

Author (S) Details

Prof. Dr. Laila M. Break
Taif University, Al-Haweiah, P.O.Box 888 Zip Code 21974, Taif, Saudi Arabia.

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