Encapsulation of Anti-dyslipidemic Drug as a Controlled Release Tablet Using Proanthocyanidin Polymer

Many people today are at high risk of coronary heart disease, and few drugs are available to assist them achieve their lipid goals. Niacin is one of the most promising drugs for dyslipidemia, with impressive lipid profile improvements. Nicotinic acid (Niacin) is the most effective medication for changing lipid diseases such as raised non-HDL cholesterol, elevated lipoproteins, elevated triglycerides, and lowering HDL cholesterol, and is thus useful in reducing residual cardiovascular risk and dyslipidemia. We will discuss extended release dosage forms, factors that cause dyslipidemia and its symptoms, nicotinic acid mechanism, applications, and how it aids in the treatment of dyslipidemia, proanthocyanidin polymer, and the development of nicotinic acid controlled release tablet with proanthocyanidin polymer using the encapsulation technique in this book. The goal of this method of creating nicotinic acid tablets is to establish a constant drug level in plasma with fewer oscillations by releasing the medication slowly over time. The encapsulation efficiency was 99.73 percent and the drug content was 99.52 percent. The medicine was released at a rate of 97.2 percent for up to 12 hours, and at a rate of 97.74 percent for 11 hours. The medication was released in a zero-order sequence. The findings suggested that NA controlled-release tablets created using encapsulation are more effective than traditional dosage forms and have improved patient compliance. This book experiments and studies the efficacy of nicotinic acid in decreasing cholesterol levels and treating dyslipidemia, as well as the efficacy of nicotinic acid as a controlled release.

Author(s) Detalis

Ravi Manne
Environmental & Industrial Hygiene Services, Chemtex, Port Arthur, Texas, USA.

Agilandeswari Devarajan
Research & Development, Synapsesai India Private Limited, Indore, Uttar Pradesh, India.

View Book:- https://stm.bookpi.org/EADCRTUPP/article/view/1890

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