A Randomised Study to Compare the Efficacy and Tolerability of Aceclofenac and Diclofenac in Osteoarthritis of Knee Joint

Background: Osteoarthritis is a slowly progressive condition characterized by hyaline cartilage loss. Nonsteroidal anti-inflammatory drugs are important in the treatment of osteoarthritis. Objectives: The purpose of the study was to compare the efficacy and tolerability of Aceclofenac and Diclofenac in patients with knee osteoarthritis. Material and Methods: This is a double-blind, randomized parallel group study. The study included 60 patients with confirmed knee osteoarthritis; 30 were given Aceclofenac and 30 were given Diclofenac after food for 8 weeks, and the patients were evaluated and compared. Pain intensity by VAS Score, joint tenderness, swelling, erythema, pain on movement, functional capacity, and overall assessment on the LIKERT Scale were all statistically significant. Both drugs resulted in significant improvements in the parameters of pain intensity, joint tenderness, swelling, erythema, and pain on movement of the OA knee joint, but aceclofenac resulted in greater improvement in all parameters. Conclusion: Aceclofenac is the preferred NSAID for osteoarthritis of the knee joint over Diclofenac because it is more effective. However, there was no significant difference in the adverse effect drug profile.

Author (S) Details

Dr. Arshiya Sehgal
Government Medical College, Patiala, Punjab, India.

Dr. Vijay K. Sehgal
Department of Pharmacology, Government Medical College, Patiala, Punj

View Book :- https://stm.bookpi.org/HMMS-V3/article/view/1601

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