The study’s goal was to create and test buccal-adhesive tablets of Buspirone HCl that avoid gastric degradation and first pass metabolism, increasing drug bioavailability and onset of action. Buspirone HCl is an anxiolytic agent as well as a serotonin receptor agonist from the azaspirodecanedione class of compounds. Methods: In this study, different ratios of Gantrez MS 955 and Carbopol 934 were studied to determine bioadhesive strength. A 32 full factorial design was used to investigate the combined effect of Carbopol 934 concentration (X1) of 5,7.5,10 mg and Gantrez MS 955 concentration (X2) of 10,12.5,15 mg. The results of the multiple regression analysis revealed that the independent variables (bioadhesive strength (Y1), Q2 (Y2), Q3 (Y3), and Q4 (Y4)) had a significant effect on the dependent variables (bioadhesive strength (Y1), Q2 (Y2), Q3 (Y3), and Q4 (Y4)). Based on multiple linear regression analysis and contour plot evaluation, it was discovered that the combination of two polymers had excellent mucoadhesive properties, allowing for easy application and removal of the tablets from the buccal mucosa. Conclusion: The formulation batch A9 met all of the criteria established during the desirability search. The optimized batch’s flux was calculated based on the in vitro diffusion study. The effect of tablet diameter and environmental factors on tablet bioadhesion was investigated. Prehydration time and contact time were considered to study the environmental factor on bioadhesion. The results revealed that increasing the prehydration time decreased bioadhesive strength while increasing the contact time increased bioadhesive strength. As a result, a stable Buccoadhesive formulation optimized for formulation ingredients and process parameters was successfully prepared.
Author (S) Details
Department of Industrial Pharmacy, Shree S.K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana, Gujarat, India.
Department of Pharmaceutics, Akshar-Preet Institute of Pharmacy Jamnagar, Gujarat, India.
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