Studies on Increasing Prevalence of Osteoporosis, Hypothyroidism and Endogenous Oestrogen

Background: During the adoption of contraception as part of the Family Welfare Program between 1983 and 1989, women reported crippling low back aches and weight increase that they attributed to puerperal sterilisation. As a result, we looked for any possible links to contraception.

Methods: Between 1995 and 2012, we conducted a retrospective investigation of the prevalence of osteoporosis and hypothyroidism in 350 patients aged 20 to 35 years, 35 to 50 years, and >50 years, using data gathered using a simple, stratified random selection of different geographical sites. We also looked at whether or not it was linked to contraception and abortion. Serum oestrogen levels from 105 patients were also tested at the same time.

Results: In contraceptive users aged >35 years, we found a 6 fold increase in hypothyroidism [p 0.0005], 3 fold increase in hypothyroidism among >20 years age group [p 0.02], and 1.5 fold increase in >50 years age group [p 0.025]. We also found a 6 fold increase in hypothyroidism among contraceptive users aged >35 years [p 0.0005], 3 fold increase in hypothyroidism among >20 years age group [p With a p value of 0.0005, endogenous oestrogen was lowered in 61 percent of people who used contraception.

Conclusion: Contraception prevents germ cells from traversing the normal path, resulting in smashed fragmentation of germ cells and decreased endogenous oestrogen or androgen, resulting in a defaulted genomic repertoire, deranged cell cycle and cell metabolism, and metabolic syndrome, with an increase in osteoporosis and hypothyroidism.

Author (s) Details

Elizabeth JeyaVardhini Samuel
Department of General Medicine, Pondicherry Institute of Medical Sciences, Pondicherry, India.

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