Study on Correlation between Troponin-I Level with Left Ventricular Systolic Dysfunction after First Attack of Non-ST Segment Elevation Myocardial Infarction

Background: Coronary Heart Disease (CHD) is the most common type of heart disease, and it is the leading cause of death in the developed world. It’s crucial to recognise an ACS patient because the diagnosis triggers both triage and treatment. CHD is the cause of more than half of all cardiovascular disease in people. cTnI is a myocardium-specific tissue marker that has been shown to be both sensitive and specific for AMI. Ventricular function is the best predictor of death after an ACS. It’s a myocardial damage indicator that also tells you about systolic function, diagnosis, and prognosis. The study’s goal was to see if LVEF had an effect on high Troponin-I levels in patients who were having their first NSTEMI event. A cross-sectional analytical study was conducted in the cardiology department of Mymensingh Medical College Hospital from December 2015 to November 2016. A total of 130 first-time NSTEMI patients were included in the study, based on inclusion and exclusion criteria. Two groups of people were chosen from the sample population: Patients in Group I had their first NSTEMI episode and had an LVEF of less than 55%. Group–II: Patients who have had their first NSTEMI incident and have an LVEF of less than 55%. Then, using Pearson’s correlation coefficient test, the levels of LVEF and Troponin-I were connected. The mean Troponin-I levels in groups I and II were 5.537.33 and 16.4615.79 ng/ml, respectively, in this investigation. There was a statistically significant difference (p0.05). The mean LVEF for the two groups was 65.3110.30 percent and 40.174.62%, respectively. There was a statistically significant difference (p 0.05). According to echocardiography, patients with a high Troponin-I level had a poor LVEF, while those with a low Troponin-I level had a preserved LVEF. Patients with the highest Troponin-I levels had severe left ventricular systolic dysfunction (LVEF 35%), while those with the lowest levels had severe left ventricular systolic dysfunction (LVEF 35%). Troponin-I levels were low, although systolic function was intact (LVEF was 55%). Troponin-I levels displayed a negative correlate with LVEF levels with a medium strength of association (r= -0.5394, p=0.001), according to our findings. Troponin-I levels of 6.6 ng/ml were also revealed to be a sensitive and specific marker for LV systolic dysfunction in our investigation. Conclusion: The researchers discovered that in NSTEMI patients with their first attack, the higher the Troponin-I level, the lower the LVEF level, and therefore the more severe the LV systolic dysfunction.

Author(s) Details

Dr. Mahmood Hasan Khan
Department of Cardiology, United Hospital Limited, Dhaka, Bangladesh.

Mirza Md. Nazrul Islam
Department of Cardiology, Mymensingh Medical College and Hospital, Mymensingh, Bangladesh.

Md. Shafiqul Islam
Department of Epidemiology, National Institute of Preventive & Social Medicine (NIPSOM), Dhaka, Bangladesh.

Kaisar Nasrullah Khan
Department of Cardiology, United Hospital Limited, Dhaka, Bangladesh.

Md. Shamim Chowdhury
Department of Cardiology, National Heart Foundation Hospital & Research Institute, Bangladesh.

Reazur Rahman
Department of Cardiology, United Hospital Limited, Dhaka, Bangladesh.

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