Determination of Mass Acquisition of Human Periodontal Ligament Stem Cell

The periodontal ligament (PDL) is a fibrous tissue that helps keep teeth in place in the alveolar bone socket. In addition, PDL tissue cushions occlusal force, maintains alveolar bone height, allows orthodontic tooth movement, and connects tooth roots to bone. Severe periodontitis, deep cavities, and trauma damage this tissue irreversibly, eventually resulting in tooth loss due to the destruction of tooth retention. These diseases affect a large number of people around the world, and their prevalence rises with age. To address this problem, regenerative therapy for PDL tissue that has been injured as well as The potential and effectiveness of stem cells, scaffolds, and cytokines, as well as their combination uses, have been widely explored in the surrounding tissues. PDL stem cells (PDLSCs) have received a lot of attention. Because of the restricted number of PDLSCs available in vivo, I present thorough investigations on PDLSCs performed in vivo and recent findings concentrating on the acquisition of large numbers of PDLSCs for therapeutic applications in this review.

Hidefumi Maeda
Department of Endodontology and Operative Dentistry, Kyushu University, 3-1-1 Maidashi, Fukuoka 8128582, Japan.

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