Determination of Efficacy and Safety of α-keto Analogs of Essential Amino Acids Supplementation in Patients of Chronic Kidney Disease: A Clinical Evaluation

The goal of this study was to see if -keto analogues of essential amino acids (KAA) as a supplement could help those with chronic renal disease (CKD). Methods: A prospective comparative study in patients with CKD was conducted in a tertiary care hospital in North India. The patients were divided into two interventional groups. Patients in Group I (control) received conservative management and placebo, while patients in Group II (KAA) received conservative management and KAA (600 mg, thrice daily) for 12 weeks. At 0, 4, 8, and 12 weeks of medication, hemograms, renal function tests, lipid profiles, and side events were all reported. Results: Both groups improved gradually in clinical characteristics after 12 weeks of treatment, albeit the KAA group improved more pronouncedly than the control group. In comparison to their pre-treatment levels, both groups showed a sustained improvement in biochemical markers, with the KAA supplemented group exhibiting a higher improvement. The levels of creatinine and total urine protein were both lower after 24 hours. The glomerular filtration rate, haemoglobin, and total urine volume in 24 hours all rose. The KAA group showed a significant (p0.05) improvement in lipid profiles when compared to the control group. There was no significant difference between the two groups in terms of side effects (p>0.05). Conclusion: KAA supplementation in combination with conservative therapy is beneficial and safe in delaying disease progression in patients with CKD.

Author(s) Details

Dr. Irfan Ahmad Khan
Department of Pharmacology, J.N. Medical College Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

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