Saussurea lappa: Possible Relief for Migraine Patients

Migraine headaches are a highly prevalent condition. Individual productivity loss as a result of migraines has social and economic consequences for society, and migraine treatment has major economic and social consequences as well. Saussurea lappa root has been utilised for medical purposes since ancient times because it has a variety of therapeutic benefits as a headache cure. This research looked at the effects of Saussurea lappa on migraine sufferers in a clinical trial. Before and after therapy, blood samples were tested to determine liver, kidney, and haematological parameters. Because serotonin and its precursor tryptophan, magnesium, and calcium have a role in migraine development, their amounts were measured before and after treatment. The 42 participants were separated into three groups: Group I (22 patients) received Saussurea lappa treatments (1 g/500 ml/day); Group II (controls) received the same therapy with the same dose of Saussurea lappa; and Group III (patients) received antimigraine medicines (Amitriptyline 20 mg/day and Ibuprofen 400 mg/day). Except for calcium, there were no significant differences in the concentrations of liver, renal function, or haematological markers before or after treatment. Headaches are commonly linked to high calcium levels. The results showed that after therapy with Saussurea lappa, calcium levels in patients reduced, indicating that this root may have an effect on headache relief via lowering calcium levels. Because magnesium and serotonin, as well as its precursor tryptophan, are both significantly reduced during migraines, this study looked at both. After two weeks of treatment, the control group had higher magnesium and serotonin levels, while patients had slightly lower levels after treatment with Saussurea lappa. This could be owing to the fact that the treatment was not lengthy enough to yield meaningful results. Saussurea lappa was proven to be a safe and effective alternative treatment drug in this investigation. Saussurea lappa, migraine, and serotonin are the key words.

Author (S) Details

Wadiah Saleh Backer
King Abdulaziz University, Biochemistry Department, P.O. Box 42737, Jeddah 21551, Saudi Arabia.

Amin A. Aljefri
King Abdulaziz University, Biochemistry Department, P.O. Box 42737, Jeddah 21551, Saudi Arabia.

Najwa Alsawy
King Abdulaziz University, Biochemistry Department, P.O. Box 42737, Jeddah 21551, Saudi Arabia.

Lina Baz
King Abdulaziz University, Biochemistry Department, P.O. Box 42737, Jeddah 21551, Saudi Arabia.

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