Studies on Kinetics and Mechanism of Oxidation of GSH by cis-(diaqua)-bis-(ethylenediamine) Cobalt(III) Ion

Using 103[Co(III)] = 5 mol dm-3, 2.5 102[GSH] 10.00 mol dm-3, 3.5 pH 5.0, 318K T 333K at a fixed ionic strength I = 0.3 mol d-3, the kinetics of GSH oxidation to GSSG by cis-(diaqua)-bis-(ethylenediamine) cobalt(III) perchlorate were examined spect (NaClO4). The first-order kinetic trend in the depletion of [Co (III)] at 500 nm with time was observed. It was discovered that [GSH] and pH had a first-order relationship. For the Co(III)-OH23+(k1) and Co(III)-OH2+(k2) reactivities, the temperature dependency of the second order rate constant k’2 = kobs/[GSH] was investigated. Co(III) and GSH form an outer-sphere complex, which is followed by a one-electron transfer from GSH to Co(III), resulting in the creation of Co(II) and GSH radicals. The GSH radical dimerizes quickly to form GSSG. The parameters of activation were computed. The electron transfer process is favoured by these values. The ordered transition state corresponds to a negative activation entropy value.

Author (S) Details

B. Mohanty
Department of Chemistry, Utkal University, Bhubaneswar, 751004, Odisha, India.

J. Behera
Department of Chemistry, Utkal University, Bhubaneswar, 751004, Odisha, India.

S. Acharya
IMMT, Bhubaneswar, Odisha, India.

P. Mohanty
Department of Chemistry, Utkal University, Bhubaneswar, 751004, Odisha, India.

A. K. Patnaik
Ravenshaw University, Cuttack, 753003, Odisha, India.

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