Determination of Histogenesis of Human Kidney in Spontaneously Aborted Human Fetuses from 14 Weeks to 36 Weeks

Aims and Objectives: Kidney development is a two-part process that includes collecting and excretory functions. Premature newborns can now live thanks to recent developments in medical science. Prenatal diagnosis of normal and congenital disorders such as Wilm’s tumour, Hydronephrosis, Multicystic dysplastic kidney, Autosomal recessive polycystic kidney disease, Megacystis, Renal dysplasia, and others requires a thorough understanding of human foetal kidney morphology and developmental anatomy.

The Histogenesis of the Kidney by Gestational Age provides an overview of various congenital defects that are helpful for a developmental anatomist in detecting genetics, radiological and histopathological diagnosis, and eventually improving antenatal screening and anticipating therapeutic options.

The researchers employed 40 kidneys from 20 spontaneously aborted foetuses [11 boys and 9 females] with gestations ranging from 14 to 36 weeks. They were gathered and processed into slides stained with hematoxylin and eosin after CRL confirmed their age. Under a light microscope, the stained slides were examined.

By 36 weeks, all kidneys had been lobulated and fused, indicating that they were lobulated and fused at an early gestational age. The corticomedullary junction and preformed collecting tubules were clearly seen after 18 weeks. Well-differentiated PCT and DCT have established by 19 to 23 weeks. By 28 weeks, well-formed pyramids and medullary rays were plainly visible, and by 29 weeks, medullary rays were definitely visible. By 28 weeks, the Henle Loop had formed and became distinct. By 32 to 36 weeks, there was an increase in vascularity. By 36 weeks, the nephrogenic zone and undifferentiated mesenchyme had diminished, whereas developed glomeruli had risen.

Conclusion: The findings of this study may aid in the understanding of a variety of renal illnesses. This research can also focus on the development of each component in the medulla and cortex of the kidney in terms of histological maturity and functional status according to gestational age, providing us with a comprehensive picture.

Author (S) Details

Divya Jain Pokarna
Kamineni Academy of Medical Sciences and Research Centre, LB Nagar, Hyderabad (500068), Telangana, India.

Kasturi Kshitija
Department of Pathology, Bhaskar Medical College And General Hospital, Hyderabad, Telangana, India.

Seethamsetty Saritha
Department of Anatomy, Kamineni Academy of Medical Sciences And Research Centre, Lb Nagar, Hyderabad (500068), Telangana, India.

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