Monomelic Amyotrophy after Permethrin Poisoning: A Case Study

Hirayama illness is a type of monomelic amyotrophy (MMA) (HD). Hirayama documented 12 individuals in the first report in 1959 [1], and a large group of patients from Japan was later discovered [2,3]. In 1984, MMA from South India was also recorded [4]. Males made up over 80% of the cases, notably those between the ages of 15 and 25. The condition is defined as unilateral or bilateral asymmetric atrophy of the hand and forearm with sparing of the brachioradialis, resulting in an oblique amyotrophy look. Disease that is symmetrically bilateral has also been identified. A cervical flexion myelopathy is suspected [5].

Because of their tremendous efficacy, pyrethroids are utilised as insecticides. These are very toxic to a variety of insects but are not harmful to humans. In humans, pyrethroids have been linked to neurotoxicity such as seizures, tremors, and disorientation. Acute toxicity from pyrethroids and organochlorines has resulted in motor neuron damage [6], while chronic exposure has resulted in MND (Motor neuron disease)-like symptoms [7]. A instance of monomelic amyotrophy has been recorded after significant intake of permethrin, amytriptyline, and benzodiazepine tablets.

Author (S) Details

Dr. Sandip Kumar Dash
Department of Neurology, Apollo Hospital, Dhaka, Bangladesh.

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