An Observational Study on Serum Carboxy Methyl Lysine, Insulin Resistance and Sensitivity in Type 2 Diabetes Mellitus and Diabetic Nephropathy Cases

Diabetes Mellitus (DM) and one of its subtypes, type 2 diabetes mellitus (T2DM), are more common in adolescents around the world, regardless of heredity or age. Under a healthy diet, food restriction will cope and assist the body metabolism in absorbing the essential nutrition and eliminating the trash from the body. Insulin resistance (IR) and decreased insulin sensitivity (IS) come from masking insulin action on target cells, resulting in increased glycated products such as glycated haemoglobin, glycated albumin, and other glycated macromolecules known as Advanced Glycation End products. BMI, along with AGE and diabetes profile, is another factor to consider. Insulin and lipid profiling could assist researchers understand the link between CML and glucose metabolism in diabetics and diabetic nephropathy. Glycoxidation and lipoxidation combine to generate CML. The study’s goals include establishing a link between CML and essential diabetes and insulin profiles in order to provide evidence for labelling CML as a hazardous chemical. Basic renal profile was done to examine kidney function and see whether it had anything to do with CML. In group 2, CML was positively connected with HbA1c, TG, and HOMA IR and negatively correlated with QUICKI, indicating greater tissue damage due to the combined effects of glucose, lipid, and insulin resistance. Regularly monitoring plasma CML and HbA1c during follow-up may assist keep track of plasma glucose status and its harmful consequences on tissues, preventing tissue and arterial lining erosion.

Author (S) Details

R. Sai Deepika
Department of Biochemistry, Sri Devaraj Urs Medical College, Kolar, India.

K. N. Shashidhar
Department of Biochemistry, Sri Devaraj Urs Medical College, Kolar, India.

A. Raveesha
Department of General Medicine, Sri Devaraj Urs Medical College, Kolar, India.

C. Muninarayana
Department of Community Medicine, Sri Devaraj Urs Medical College, Kolar, India.

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