Study on Metastatic Clear Cell Hidradenocarcinoma: An Approach towards Response to Chemotherapy and Long Disease Control
Introduction: Hidradenocarcinoma is a rare aggressive tumour of the sweat glands that can arise from a preexisting hidradenoma or develop spontaneously. It most commonly affects elderly individuals and is mostly found in the head, neck, and trunk. This tumour is also known for its high risk of local recurrence, metastasis, and poor prognosis. This tumour is frequently resistant to radiation and chemotherapy. We present evidence of a good clinical response with lengthy disease control in metastatic hidradenocarcinoma treated with capecitabine.
Case Presentation: We present the case of a 77-year-old man who was operated on 7 years ago for a hidradenoma of the right foot and now has metastatic hidradenocarcinoma to the bone and lymph nodes. He was treated with capecitabine-based chemotherapy for ten months, with good tolerability and a partial response. His condition worsened after that, and he died a year after being diagnosed.
Hidradenocarcinoma is a malignancy that has a bad prognosis. Its therapy is still debatable due to its low prevalence and high rate of recurrence. Our positive outcome suggests that adding chemotherapy to a metastatic form of cancer improves control and extends overall survival.
Author (S) Details
Mouna Ayadi
Department of Medical Oncology, Salah Azaiez Hospital, Tunis, Tunisia.
Feryel Letaief
Department of Medical Oncology, Salah Azaiez Hospital, Tunis, Tunisia.
Khadija Meddeb
Department of Medical Oncology, Salah Azaiez Hospital, Tunis, Tunisia.
Amina Mokrani
Department of Medical Oncology, Salah Azaiez Hospital, Tunis, Tunisia.
Yosra Yahyaoui
Department of Pathology, Internal Security Forces Hospital, Marsa, Tunisia.
Nesrine Chrait
Department of Pathology, Internal Security Forces Hospital, Marsa, Tunisia.
H. Henda Rais
Department of Pathology, Internal Security Forces Hospital, Marsa, Tunisia.
Khadija Bellil
Department of Pathology, Internal Security Forces Hospital, Marsa, Tunisia.
Amel Mezlini
Department of Pathology, Internal Security Forces Hospital, Marsa, Tunisia.
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