In the tropics and subtropics, malaria is a serious infectious illness. Antimalarial drug resistance in P. falciparum has required the quest for new antimalarial agents. Vernonia amygdalina, a plant used by traditional healers to cure malaria and other ailments, was tested in vitro against 14 fresh isolates of Plasmodium falciparum from Damboa, Borno State, Nigeria. Acute toxicity and anti-inflammatory effectiveness of the extracts were also investigated. In comparison to controls, schizont development was significantly slowed. (The significance level is set at 0.05). The antimalarial activity of ethanolic extract was 78.10 percent with an IC50 of 11.2 g/ml, while aqueous extract was 74.02 percent with an IC50 of 13.6 g/ml. The antimalarial activity of both extracts was moderate. The extracts were shown to be non-toxic in rats and to have a high level of anti-inflammatory action. This research backs up the plant’s long-standing use in malaria treatment. To isolate, identify, and characterise the active components in the plant, more research is required.
Author (S) Details
K. K. Sha’a
College of Science and Technology, Adamawa State Polytechnic, P.M.B. 2146, Yola, Nigeria and University of Jos, P.M.B. 2084, Jos, Nigeria.
Department of Paediatrics, Jos University Teaching Hospital, Jos, Nigeria.
I. M. Watila
Department of Paediatrics, State Specialist Hospital, P.M.B. 1014, Maiduguri, Borno State, Nigeria.
T. F. Ikpa
Department of Wildlife, University of Agriculture, P.M.B. 2373, Makurdi, Nigeria.