Study on Pharmacogenomics in Oral Diseases

We now have a better understanding of the genetic variations that cause the majority of human diseases because to the availability of modern technology for detecting and characterising the human genome. The human genetic sequence varies by less than 1% between population groups, and these variations, known as gene polymorphisms, are the primary cause of individual variability in drug therapy response. Understanding genetic variances may also allow for the implementation of targeted medication, resulting in more effective treatment options and fewer undesirable side effects. Pharmacogenomics is a branch of personalised medicine that focuses on the genetics of drugs. At the genome-wide level, determinants of pharmacological response. It focuses on customising medication therapy for each individual based on their genetic makeup, as well as discovering new therapeutic targets in a variety of diseases. While pharmacogenomics has been extensively researched in the context of systemic illness, little is known about its involvement in oral ailments. Identifying particular targets in periodontitis, head and neck cancer, infections, and hereditary abnormalities can help in the creation of new drugs. This chapter discusses the basics of pharmacogenomics, as well as its current and potential applications in a number of head and neck illnesses.

Author (S) Details

Dr. Sridharan Gokul
Department of Oral Pathology and Microbiology, YMT Dental College and Hospital, Kharghar, Navi Mumbai-410210, Maharashtra, India.

Dr. Gokul Sapna
Department of Periodontics, Nair Hospital Dental College, Mumbai-400008, Maharashtra, India.

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