The in vitro Pharmacological Effects of Fagonia cretica Linn Ethanolic Extract on Isolated Rabbit Intestine
The purpose of this study was to examine the pharmacological effect(s) of the Fagonia cretica linn (Zygophyllaceae) ethanolic extract on isolated rabbit intestine and to determine the mechanism(s) underlying its activity using isolated rabbit intestine. The cumulative dose-response curves of Fagonia cretica extract and standard adrenaline were generated using different dosages ranging from (10-3 – 102 g/ml) and (10-9 – 10-5 M) alone, as well as in the presence of a single dose of a blocker, and the values of EC50, Emax, and pA2 were calculated. The results were calculated as mean S.E.M. and statistically compared. To determine the specific mechanism mediating the calming effect of Fagonia cretica linn’s ethanolic extract, the non-selective adrenergic blockers phentolamine and propranolol were used in concentrations of (10-8 and 10-5 M). On rabbit intestine, Fagonia cretica displayed a dose-dependent relaxant activity comparable to that of normal adrenaline, with Emax= [56.4 7.5], [7.2 4.3] and EC50= [0.12 0.27], [9.85 1.6] x 10-6, respectively. No direct muscle relaxant was implicated in mediating the relaxing effect of the plant extract, which was mediated by both and adrenoceptors. It was proposed that more in-depth study be undertaken using multiple methodologies to further analyse and confirm these findings.
Author (s) Details
Aimun A. E. Ahmed
Department of Pharmacology, Faculty of Pharmacy, Omdurman Islamic University, P.O. Box 382, Sudan and Department of Pharmacology, Faculty of Medicine, Al Baha University, P.O. Box 1988, KSA.
Mawahib E. H. Elfeil
Department of Pharmacology, Faculty of Pharmacy, International University of Africa, P.O. Box 83, Sudan.
Samrin K. N. Ahmed
Department of Pharmacology, Faculty of Pharmacy, International University of Africa, P.O. Box 83, Sudan.
Tasnim O. Elsammani
Department of Pharmacology, Faculty of Pharmacy, International University of Africa, P.O. Box 83, Sudan.
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