Determining the Prostate Cancer Road Map Hypothesis in 49 Countries: From Iron-Deficiency Anemia (IDA) to Death

Background: Deaths due to prostate cancer (PCa) in 2016 had in common iron deficiency anaemia (IDA) in 2000, according to a follow-up analysis of the San Valentino (Italy) screening of cardiovascular illnesses.

Aims: The study compared total mortality for PCa in terms of ASDRs (Age-Standardized-Death Rate x 100000 population) to ASDRs of IDA and diseases that may cause IDA from the year 2000 to ASDRs of IDA and diseases that may cause IDA.

Methods: Researchers looked at the relationship between PCa, IDA, and 16 additional variables that could be linked to IDA in 49 nations. The ASDRs (Age-Standardized Death Rate x 100000 population) were used to extract data from WHO records (2018) in 49 countries for the years 2000, 2010, and 2016. WHO assessed the 49 selected countries (SC) to have “excellent completeness and quality of cause-of-death assignment” and “may be used for priority setting and policy evaluation.” PCa, IDA, and 16 diseases: TB, gonorrhoea, syphilis, and chlamydia in females, other sexually transmitted diseases (STDs in both genders), diarrheal diseases, stomach ulcers, cirrhosis, IDA, HIV, digestive diseases, respiratory infections, and alcohol and drug addictions. Cluster analysis, Multivariate analysis, and the Residual Normal Quantile Plot were used to calculate the correlations with PCa.

PCa was found to be associated with IDA, HIV, chlamydia in females, and digestive illnesses. All of the other variables were found to be unrelated. The total ASDRs were greatly improved in terms of mean values (-25 percent ). However, the variations were extremely significant in most of the disorders, implying that averages and percent reductions should be used with caution.

Conclusions: PCa appears to follow a path that includes IDA, immunological depression, and chlamydia infections. Other than gastric ulcers and cirrhosis, digestive diseases are only marginally predictive. A viable approach to guard against PCa is chlamydia vaccine. Long-term prospective research should be evaluated.

Author (S) Details

Cornelli Umberto
Loyola University School of Medicine Chicago, USA.

Belcaro Giovanni
IRVINE LABS, University of Chieti, Italy.

Recchia Martino
University of Lugano, Switzerland.

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