Maternal Serum Biochemical Indicators of Trophoblastic Cell and Endothelial Function at First Trimester of Pregnancy

Background: Preeclampsia is a worldwide pregnancy complication, and one of the most important goals in obstetrics is to identify patients who are at an increased risk early. The exact cause of preeclampsia is unknown, but it is thought that a problem with early placentation is linked to the disorder’s pathogenesis. With basal values of the biochemical markers related with the underlying placentation process, first trimester screening is critical over the second trimester for understanding the early beginning of the illness. The goal of this study is to determine the levels of serum biochemical markers in pregnant women during the first trimester, as well as the statistical significance and correlation of the data in support of trophoblastic cell integrity, endothelial function, and oxidative stress. Materials and Procedures: A longitudinal study was conducted on 86 pregnant women between the ages of 20 and 35 who were primigravidas with a singleton pregnancy and visited a prenatal checkup between 11 and 13 weeks of pregnancy. ELISA was used to test maternal serum for Placental protein 13 (PP13), Caspase 3, Asymmetric dimethylarginine (ADMA), and Nitric oxide (NO). The activity of xanthine oxidase (XO) was measured spectrophotometrically. A dry chemical analyser was used to quantify calcium and uric acid (UA). The mean SD values for mean arterial pressure (MAP) are 108.4 18.9, UA 2.01 0.85, TOS 12.83 5.17, TAC 24.10 14.28, XO 1.01 2.67, Caspase-3 1.76 2.22, PP13 489.77 53.6, Calcium 10.88 1.97, ADMA 19.03 17.08, and NO 1.16 0.75. Positive correlations were found between ADMA and Caspase-3 (r = +0.435), PP13 and NO (r = +0.241), TOS and TAC (r = +0.176), UA and ADMA (r = +0.176), UA and TAC (r = +0.168) while negative correlations were found between PP13 and ADMA (r = 0.158), NO & TOS (r = 0.114), UA & XO (r = 0.1 Conclusion: The study found that first trimester biochemical markers and their correlation predict trophoblastic cell integrity and endothelial function during placentation under oxidative stress, which could aid in identifying women who develop preeclampsia later on.

Author (S) Details

Ranjeeta Gadde
Department of Biochemistry, Sri Devaraj Urs Medical College, SDUAHER, Tamaka, Kolar, India.

Chikkanayakanahalli Doddaiah Dayanand
Department of Biochemistry, Sri Devaraj Urs Medical College, SDUAHER, Tamaka, Kolar, India.

Shimoga Rangappa Sheela
Department of Obstetrics and Gynaecology, Sri Devaraj Urs Medical College, SDUAHER, Tamaka, Kolar, India.

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